The genetically engineered, humanized, bispecific monoclonal antibody emicizumab (Hemlibra® ) that mimics the cofactor activity of activated FVIII has been approved for treatment of haemophilia A patients with and without inhibitor. In the pivotal pre-marketing clinical trials emicizumab prophylaxis significantly reduced bleeding rates compared to previous treatments and was well tolerated. However, a consequence of this novel therapy may be the host immune response to a foreign protein.

Characterization of the neutralizing anti-emicizumab antibody in a patient with haemophilia A and inhibitor / C. Valsecchi, M. Gobbi, M. Beeg, T. Adams, G. Castaman, L. Schiavone, J.A. Huntington, F. Peyvandi. - In: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. - ISSN 1538-7933. - 19:3(2021), pp. 711-718. [10.1111/jth.15226]

Characterization of the neutralizing anti-emicizumab antibody in a patient with haemophilia A and inhibitor

Valsecchi, Carla;Peyvandi, Flora
2021

Abstract

The genetically engineered, humanized, bispecific monoclonal antibody emicizumab (Hemlibra® ) that mimics the cofactor activity of activated FVIII has been approved for treatment of haemophilia A patients with and without inhibitor. In the pivotal pre-marketing clinical trials emicizumab prophylaxis significantly reduced bleeding rates compared to previous treatments and was well tolerated. However, a consequence of this novel therapy may be the host immune response to a foreign protein.
anti-drug antibody; emicizumab; haemophilia; immunoassay; surveillance
Settore MED/09 - Medicina Interna
28-dic-2020
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/802011
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