We investigated longitudinally the behaviour of anti-factor VIII (anti-FVIII) IgG subclasses for 6 months from inhibitor development in 43 patients from the Survey of Inhibitors in Plasma-Products Exposed Toddlers (SIPPET) trial who developed persistent or transient inhibitors. We first analysed 43 patients within 60 days post inhibitor detection. Then, 14 of these 43 patients were studied at five time points over 6 months. Our study showed that during the first 60 days, the risk of inhibitor persistence increased with the concomitant presence of an increasing number of IgG subclasses. Over the 6-month period post inhibitor detection, only the IgG2 subclass could be considered a hallmark of inhibitor persistence.

IgG subclasses as biomarkers for persistence of factor VIII inhibitors in previously untreated patients with severe haemophilia A / F. Peyvandi, S. Miri, P. Bucciarelli, C. Valsecchi, L. Schiavone, M. Boscarino, R. Palla, P.M. Mannucci, F.R. Rosendaal. - In: BRITISH JOURNAL OF HAEMATOLOGY. - ISSN 0007-1048. - (2020 Dec 14). [Epub ahead of print] [10.1111/bjh.17249]

IgG subclasses as biomarkers for persistence of factor VIII inhibitors in previously untreated patients with severe haemophilia A

Peyvandi F.;Miri S.;Bucciarelli P.;Valsecchi C.;Palla R.;Mannucci P. M.;
2020-12-14

Abstract

We investigated longitudinally the behaviour of anti-factor VIII (anti-FVIII) IgG subclasses for 6 months from inhibitor development in 43 patients from the Survey of Inhibitors in Plasma-Products Exposed Toddlers (SIPPET) trial who developed persistent or transient inhibitors. We first analysed 43 patients within 60 days post inhibitor detection. Then, 14 of these 43 patients were studied at five time points over 6 months. Our study showed that during the first 60 days, the risk of inhibitor persistence increased with the concomitant presence of an increasing number of IgG subclasses. Over the 6-month period post inhibitor detection, only the IgG2 subclass could be considered a hallmark of inhibitor persistence.
haemophilia A; IgG subclasses; inhibitor; predictive biomarkers
Settore MED/09 - Medicina Interna
BRITISH JOURNAL OF HAEMATOLOGY
Article (author)
File in questo prodotto:
File Dimensione Formato  
bjh.17249.pdf

non disponibili

Tipologia: Publisher's version/PDF
Dimensione 87.52 kB
Formato Adobe PDF
87.52 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/801961
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
social impact