3D printing, and particularly fused deposition modeling (FDM), has rapidly brought the possibility of personalizing drug therapies to the forefront of pharmaceutical research and media attention. Applications for this technology, described in published articles, are expected to grow significantly in 2020. Where are we on this path, and what needs to be done to develop a FDM 2.0 process and make personalized medicines available to patients? Based on literature analysis, this manuscript aims to answer these questions and highlight the critical technical aspects of FDM as an emerging technology for manufacturing safe, high-quality personalized oral drug products. In this collaborative paper, experts from different fields contribute strategies for ensuring the quality of starting materials and discuss the design phase, printer hardware and software, the process, the environment and the resulting products, from the perspectives of both patients and operators.
Quality considerations on the pharmaceutical applications of fused deposition modeling 3D printing / A. Melocchi, F. Briatico-Vangosa, M. Uboldi, F. Parietti, M. Turchi, D. von Zeppelin, A. Maroni, L. Zema, A. Gazzaniga, A. Zidan. - In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. - ISSN 0378-5173. - 592(2021 Jan 05).
|Titolo:||Quality considerations on the pharmaceutical applications of fused deposition modeling 3D printing|
MELOCCHI, ALICE (Primo) (Corresponding)
ZEMA, LUCIA (Corresponding)
GAZZANIGA, ANDREA (Penultimo)
|Parole Chiave:||3D printing; Drug product fabrication; Fused deposition modeling; Quality; Safety|
|Settore Scientifico Disciplinare:||Settore CHIM/09 - Farmaceutico Tecnologico Applicativo|
|Data di pubblicazione:||5-gen-2021|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.ijpharm.2020.119901|
|Appare nelle tipologie:||01 - Articolo su periodico|