3D printing, and particularly fused deposition modeling (FDM), has rapidly brought the possibility of personalizing drug therapies to the forefront of pharmaceutical research and media attention. Applications for this technology, described in published articles, are expected to grow significantly in 2020. Where are we on this path, and what needs to be done to develop a FDM 2.0 process and make personalized medicines available to patients? Based on literature analysis, this manuscript aims to answer these questions and highlight the critical technical aspects of FDM as an emerging technology for manufacturing safe, high-quality personalized oral drug products. In this collaborative paper, experts from different fields contribute strategies for ensuring the quality of starting materials and discuss the design phase, printer hardware and software, the process, the environment and the resulting products, from the perspectives of both patients and operators.

Quality considerations on the pharmaceutical applications of fused deposition modeling 3D printing / A. Melocchi, F. Briatico-Vangosa, M. Uboldi, F. Parietti, M. Turchi, D. von Zeppelin, A. Maroni, L. Zema, A. Gazzaniga, A. Zidan. - In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. - ISSN 0378-5173. - 592(2021 Jan 05). [10.1016/j.ijpharm.2020.119901]

Quality considerations on the pharmaceutical applications of fused deposition modeling 3D printing

Melocchi, Alice;Uboldi, Marco;Maroni, Alessandra;Zema, Lucia;Gazzaniga, Andrea;
2021-01-05

Abstract

3D printing, and particularly fused deposition modeling (FDM), has rapidly brought the possibility of personalizing drug therapies to the forefront of pharmaceutical research and media attention. Applications for this technology, described in published articles, are expected to grow significantly in 2020. Where are we on this path, and what needs to be done to develop a FDM 2.0 process and make personalized medicines available to patients? Based on literature analysis, this manuscript aims to answer these questions and highlight the critical technical aspects of FDM as an emerging technology for manufacturing safe, high-quality personalized oral drug products. In this collaborative paper, experts from different fields contribute strategies for ensuring the quality of starting materials and discuss the design phase, printer hardware and software, the process, the environment and the resulting products, from the perspectives of both patients and operators.
3D printing; Drug product fabrication; Fused deposition modeling; Quality; Safety
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Article (author)
File in questo prodotto:
File Dimensione Formato  
Melocchi et al. pre-print.pdf

accesso aperto

1.49 MB Adobe PDF Visualizza/Apri
Melocchi et al., 2021 Int J Pharm 592, 119901.pdf

non disponibili

1.23 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/800657
Citazioni
  • ???jsp.display-item.citation.pmc??? 9
  • Scopus 30
  • ???jsp.display-item.citation.isi??? 28
social impact