The aim of this study was to assess cerebrospinal fluid (CSF) concentrations of specific amino acids using a high-performance liquid chromatography system in a sample of patients with functional movement disorders (FMDs) and in a sample of controls. CSF levels of glutamate were significantly lower in patients with FMD than in controls. This finding argues in favor of glutamatergic dysfunction in the pathophysiology of FMD.
Cerebrospinal fluid glutamate changes in functional movement disorders / B. Demartini, R.W. Invernizzi, L. Campiglio, T. Bocci, A. D'Arrigo, A. Arighi, F. Sciacca, D. Galimberti, E. Scarpini, O. Gambini, A. Priori. - In: NPJ PARKINSON'S DISEASE. - ISSN 2373-8057. - 6:1(2020 Dec 04). [10.1038/s41531-020-00140-z]
Cerebrospinal fluid glutamate changes in functional movement disorders
B. DemartiniPrimo
;L. Campiglio;T. Bocci;A. D'Arrigo;A. Arighi;F. Sciacca;D. Galimberti;E. Scarpini;O. GambiniPenultimo
;A. Priori
Ultimo
2020
Abstract
The aim of this study was to assess cerebrospinal fluid (CSF) concentrations of specific amino acids using a high-performance liquid chromatography system in a sample of patients with functional movement disorders (FMDs) and in a sample of controls. CSF levels of glutamate were significantly lower in patients with FMD than in controls. This finding argues in favor of glutamatergic dysfunction in the pathophysiology of FMD.
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