Psychiatric Disorders in Alzheimer Disease With the Presenilin-1 L226F Mutation

Bartesaghi, F.; Rosci, C.E.; Rassiga, C.; Barbieri, V.; Gambini, O.; Floro, S.; D'Arrigo, A.M.; Del Sole, A.; Scarpini, E.A.; Galimberti, D.; Priori, A.

doi:10.1097/WNN.0000000000000249

The presenilin-1 (PSEN1) L226F mutation has been linked to very early onset of prominent behavioral and psychiatric disturbances followed by cognitive decline within a few years. We report a novel case of early-onset Alzheimer disease that was originally diagnosed as psychotic depression in a patient with this gene mutation. We also compare our patient's clinical data to those of other cases of this mutation that have been described in the literature. Because atypical behavioral and psychiatric disturbances in young (<40 years) individuals can herald Alzheimer disease, a tight collaboration between psychiatrists and neurologists is crucial for an early diagnosis.

Psychiatric Disorders in Alzheimer Disease With the Presenilin-1 L226F Mutation / F. Bartesaghi, C.E. Rosci, C. Rassiga, V. Barbieri, O. Gambini, S. Floro, A.M. D'Arrigo, A. Del Sole, E.A. Scarpini, D. Galimberti, A. Priori. - In: COGNITIVE AND BEHAVIORAL NEUROLOGY. - ISSN 1543-3633. - 33:4(2020 Dec), pp. 278-282.

Titolo:	Psychiatric Disorders in Alzheimer Disease With the Presenilin-1 L226F Mutation
Autori:	BARTESAGHI, FRANCESCA ROSCI, CHIARA EMILIA RASSIGA, CECILIA BARBIERI, VALENTINA GAMBINI, ORSOLA FLORO, STEFANO D'ARRIGO, ANDREA MARIA DEL SOLE, ANGELO SILVESTRO SCARPINI, ELIO ANGELO GALIMBERTI, DANIELA PRIORI, ALBERTO (Corresponding)
Parole Chiave:	early-onset Alzheimer disease; PSEN1; genetic; behavioral symptoms
Settore Scientifico Disciplinare:	Settore MED/26 - Neurologia Settore MED/36 - Diagnostica per Immagini e Radioterapia
Data di pubblicazione:	dic-2020
Rivista:	COGNITIVE AND BEHAVIORAL NEUROLOGY
Tipologia:	Article (author)
Digital Object Identifier (DOI):	http://dx.doi.org/10.1097/WNN.0000000000000249
Appare nelle tipologie:	01 - Articolo su periodico

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