The association of microtubule (MT) breakdown with neurodegeneration and neurotoxicity has provided an emerging therapeutic approach for neurodegenerative diseases. Tubulin binders are able to modulate MT dynamics and, as a result, are of particular interest both as potential therapeutics and experimental tools used to validate this strategy. Here, we provide a comprehensive overview of current knowledge and recent advancements regarding MT-targeting approaches for neurodegeneration and evaluate the potential application of MT-targeting agents (MTAs) based on available preclinical and clinical data.

Microtubule-targeting agents and neurodegeneration / Z. Boiarska, D. Passarella. - In: DRUG DISCOVERY TODAY. - ISSN 1359-6446. - (2020 Dec 03). [Epub ahead of print] [10.1016/j.drudis.2020.11.033]

Microtubule-targeting agents and neurodegeneration

Z. Boiarska
Primo
;
D. Passarella
Ultimo
2020

Abstract

The association of microtubule (MT) breakdown with neurodegeneration and neurotoxicity has provided an emerging therapeutic approach for neurodegenerative diseases. Tubulin binders are able to modulate MT dynamics and, as a result, are of particular interest both as potential therapeutics and experimental tools used to validate this strategy. Here, we provide a comprehensive overview of current knowledge and recent advancements regarding MT-targeting approaches for neurodegeneration and evaluate the potential application of MT-targeting agents (MTAs) based on available preclinical and clinical data.
Settore CHIM/06 - Chimica Organica
Settore CHIM/08 - Chimica Farmaceutica
3-dic-2020
3-dic-2020
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/800338
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