The association of microtubule (MT) breakdown with neurodegeneration and neurotoxicity has provided an emerging therapeutic approach for neurodegenerative diseases. Tubulin binders are able to modulate MT dynamics and, as a result, are of particular interest both as potential therapeutics and experimental tools used to validate this strategy. Here, we provide a comprehensive overview of current knowledge and recent advancements regarding MT-targeting approaches for neurodegeneration and evaluate the potential application of MT-targeting agents (MTAs) based on available preclinical and clinical data.
Microtubule-targeting agents and neurodegeneration / Z. Boiarska, D. Passarella. - In: DRUG DISCOVERY TODAY. - ISSN 1359-6446. - (2020 Dec 03). [Epub ahead of print] [10.1016/j.drudis.2020.11.033]
Microtubule-targeting agents and neurodegeneration
Z. BoiarskaPrimo
;D. Passarella
Ultimo
2020
Abstract
The association of microtubule (MT) breakdown with neurodegeneration and neurotoxicity has provided an emerging therapeutic approach for neurodegenerative diseases. Tubulin binders are able to modulate MT dynamics and, as a result, are of particular interest both as potential therapeutics and experimental tools used to validate this strategy. Here, we provide a comprehensive overview of current knowledge and recent advancements regarding MT-targeting approaches for neurodegeneration and evaluate the potential application of MT-targeting agents (MTAs) based on available preclinical and clinical data.File | Dimensione | Formato | |
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