Purpose: To evaluate the feasibility and safety of a new percutaneous image-guided surgery technique to simulate a hernia repair using hydrogel. Materials and methods: A comparative prospective study was conducted in animals, with survival. Five pigs without any hernias were used. A hydrogel was injected at a site corresponding to the preperitoneal inguinal region. This procedure was performed bilaterally. An image-guided needle (ultrasound and computed tomography) was used, through which the material was injected. After survival, the local and systemic inflammatory reaction generated by the new material, was studied. Results: All animals survived the procedure. No hemorrhagic or infectious complications were reported. The solidification of the material occurred as expected. In eight out of ten cases, the material was found in the planned site. No systemic inflammatory reaction secondary to the administration of hydrogel was reported. The adhesion of the material to surrounding tissues was satisfactory. Conclusion: The introduction of a liquid material which solidifies after injection in a short time (hydrogel) using a needle is feasible. The combined CT-scan and US image guidance allows for the percutaneous placement of the needle in the required location. The introduced hydrogel remains in this space, corresponding to the inguinal region, without moving. The placed hydrogel compresses the posterior wall composed of the transversalis fascia, supporting the potential use of hydrogel for hernia defects.
Application of a novel material in the inguinal region using a totally percutaneous approach in an animal model : a new potential technique? / M.E. Gimenez, C.F. Davrieux, E. Serra, M. Palermo, E.J. Houghton, G. Alonci, E. Piantanida, A. Garcia Vazquez, V. Lindner, B. Dallemagne, M. Diana, J. Marescaux, L. De Cola. - In: HERNIA. - ISSN 1265-4906. - 23:6(2019), pp. 1175-1185.
|Titolo:||Application of a novel material in the inguinal region using a totally percutaneous approach in an animal model : a new potential technique?|
|Parole Chiave:||Direct hernia repair; Hernia repair; Hydrogel; Image-guided hernia repair; Minimally invasive hernia surgery; Abdominal Wall; Animals; Biocompatible Materials; Fascia; Feasibility Studies; Female; Groin; Hernia, Inguinal; Herniorrhaphy; Hydrogels; Male; Prospective Studies; Surgery, Computer-Assisted; Swine; Tomography, X-Ray Computed; Ultrasonography|
|Settore Scientifico Disciplinare:||Settore CHIM/03 - Chimica Generale e Inorganica|
|Data di pubblicazione:||2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s10029-019-01999-5|
|Appare nelle tipologie:||01 - Articolo su periodico|
File in questo prodotto:
|Giménez2019_Article_ApplicationOfANovelMaterialInT.pdf||Publisher's version/PDF||Administrator Richiedi una copia|