NOTCH1 is involved in the pathogenesis of T-acute lymphoblastic leukemia (T-ALL) carrying the very rare translocation t(7;9)(q34;q34.3). We analyzed the expression of genes belonging to NOTCH pathway, in acute leukemia primary samples and lymphoblastoid cell lines. NOTCH1 pathway activation represents a common feature of T-ALL when compared to acute myelogenous leukemia (AML) and B-cell precursor acute lymphoblastic leukemia. The contemporary expression of NOTCH1 and its ligands on cell surface contributes to high levels of pathway activity. AML primary samples show high levels of JAGGED1 expression despite the low NOTCH1 pathway activation, consistent with an autonomous JAGGED1 signaling in myeloid leukemogenesis. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

A wide role for NOTCH1 signaling in acute leukemia / R. Chiaramonte, A. Basile, E. Tassi, E. Calzavara, V. Cecchinato, V. Rossi, A. Biondi, P. Comi. - In: CANCER LETTERS. - ISSN 0304-3835. - 219:1(2005), pp. 113-120.

A wide role for NOTCH1 signaling in acute leukemia

R. Chiaramonte
Primo
;
A. Basile
Secondo
;
E. Calzavara;V. Cecchinato;P. Comi
Ultimo
2005

Abstract

NOTCH1 is involved in the pathogenesis of T-acute lymphoblastic leukemia (T-ALL) carrying the very rare translocation t(7;9)(q34;q34.3). We analyzed the expression of genes belonging to NOTCH pathway, in acute leukemia primary samples and lymphoblastoid cell lines. NOTCH1 pathway activation represents a common feature of T-ALL when compared to acute myelogenous leukemia (AML) and B-cell precursor acute lymphoblastic leukemia. The contemporary expression of NOTCH1 and its ligands on cell surface contributes to high levels of pathway activity. AML primary samples show high levels of JAGGED1 expression despite the low NOTCH1 pathway activation, consistent with an autonomous JAGGED1 signaling in myeloid leukemogenesis. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
AML; BCP-ALL; JAGGED1; NOTCH1; T-ALL
Settore MED/04 - Patologia Generale
Settore MED/46 - Scienze Tecniche di Medicina di Laboratorio
2005
Article (author)
File in questo prodotto:
File Dimensione Formato  
Cancer letters.pdf

accesso aperto

Tipologia: Altro
Dimensione 364.11 kB
Formato Adobe PDF
364.11 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/7844
Citazioni
  • ???jsp.display-item.citation.pmc??? 21
  • Scopus 70
  • ???jsp.display-item.citation.isi??? 61
social impact