The combination of enabling technologies, such as biocatalysis and flow chemistry, represents an important opportunity to expand the chemical toolbox for the preparation of fine chemicals and pharmaceuticals under ambient and environmentally benign conditions. Whole cells are considered as the cheapest form of catalyst for bioconversion for many reasons, among which the ready and cheap preparation, no need of expensive cofactor, and the increased enzyme stability because of protective barriers offered by cell compartments. This review highlights some of the most recent advances in the field of biotransformations under flow conditions using whole cells. Different examples are provided where the use of continuous flow techniques enables the development of very efficient processes and multiple reaction steps to be combined into a single continuous operation.
Advances on whole-cell biocatalysis in flow / A. Pinto, M.L. Contente, L. Tamborini. - In: CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY. - ISSN 2452-2236. - 25:(2020 Oct), pp. 100343.1-100343.5. [10.1016/j.cogsc.2020.04.004]
Advances on whole-cell biocatalysis in flow
A. PintoPrimo
;M.L. Contente;L. Tamborini
Ultimo
2020
Abstract
The combination of enabling technologies, such as biocatalysis and flow chemistry, represents an important opportunity to expand the chemical toolbox for the preparation of fine chemicals and pharmaceuticals under ambient and environmentally benign conditions. Whole cells are considered as the cheapest form of catalyst for bioconversion for many reasons, among which the ready and cheap preparation, no need of expensive cofactor, and the increased enzyme stability because of protective barriers offered by cell compartments. This review highlights some of the most recent advances in the field of biotransformations under flow conditions using whole cells. Different examples are provided where the use of continuous flow techniques enables the development of very efficient processes and multiple reaction steps to be combined into a single continuous operation.File | Dimensione | Formato | |
---|---|---|---|
Curr. Op. Green Sustan. Chem._Accepted.pdf
accesso aperto
Tipologia:
Pre-print (manoscritto inviato all'editore)
Dimensione
411.84 kB
Formato
Adobe PDF
|
411.84 kB | Adobe PDF | Visualizza/Apri |
1-s2.0-S2452223620300304-main.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
451.82 kB
Formato
Adobe PDF
|
451.82 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.