The so-called “sialo-chemical-biology” has become an attractive research area, as an increasing number of natural products containing a sialic acid moiety have been shown to play important roles in biological, pathological, and immunological processes. The intramolecular lactones of sialic acids are a subclass from this crucial family that could have central functions in the discrimination of physiological and pathological conditions. In this review, we report an in-depth analysis of the synthetic achievements in the preparation of the intramolecular lactones of sialic acids (1,4-, 1,7- and -lactones), in their free and/or protected form. In particular, recent advances in the synthesis of the 1,7-lactones have allowed the preparation of key sialic acid derivatives. These compounds could be used as authentic reference standards for their correct determination in biological samples, thus overcoming some of the limitations of the previous analytical procedures.
Intramolecular Lactones of Sialic Acids / P. Rota, P. La Rocca, P. Allevi, C. Pappone, L. Anastasia. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 21:21(2020 Oct 30).
|Titolo:||Intramolecular Lactones of Sialic Acids|
ROTA, PAOLA (Primo) (Corresponding)
LA ROCCA, PAOLO (Secondo)
|Parole Chiave:||lactone; sialic acid; biomarker; heptafluoro derivatives; tumor|
|Settore Scientifico Disciplinare:||Settore BIO/10 - Biochimica|
Settore MED/06 - Oncologia Medica
Settore CHIM/01 - Chimica Analitica
|Data di pubblicazione:||30-ott-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/ijms21218098|
|Appare nelle tipologie:||01 - Articolo su periodico|