The feasibility of the use of two lipid sources and their impact on the cannabinoid profile, terpene fingerprint, and degradation products in medical cannabis oil preparations during 3 months of refrigerated storage time were investigated. LCHRMS-Orbitrap(R)and HS-SPME coupled to GC-MS for the investigation of targeted and untargeted cannabinoids, terpenes, and lipid degradation products in Bedrocan(R)and Bediol(R)macerated oils were used as analytical approaches. As regards the cannabinoid trend during 90 days of storage, there were no differences between PhEur-grade olive oil (OOPH) and medium-chain triglycerides oil (MCT oil) coupled to a good stability of preparations for the first 60 days both in Bedrocan(R)and Bediol(R)oils. MCT lipid source extracted a significant concentration of terpenes compared to olive oil. Terpenes showed a different scenario since MCT oil displayed the strongest extraction capacity and conservation trend of all compounds during the shelf life. Terpenes remained stable throughout the entire storage period in MCT formulations while a significant decrease after 15 and 30 days in Bediol(R)and Bedrocan(R)was observed in olive oil. Therefore, MCT oil could be considered a more suitable lipid source compared to olive oil involved in the extraction of medical cannabis for magistral preparations.

Impact of Lipid Sources on Quality Traits of Medical Cannabis-Based Oil Preparations / A. Ramella, G. Roda, R. Pavlovic, M.D. Cas, E. Casagni, G. Mosconi, F. Cecati, P. Minghetti, C. Grizzetti. - In: MOLECULES. - ISSN 1420-3049. - 25:13(2020 Jul). [10.3390/molecules25132986]

Impact of Lipid Sources on Quality Traits of Medical Cannabis-Based Oil Preparations

G. Roda
Secondo
;
R. Pavlovic
;
M.D. Cas;E. Casagni;G. Mosconi;P. Minghetti
Penultimo
;
2020

Abstract

The feasibility of the use of two lipid sources and their impact on the cannabinoid profile, terpene fingerprint, and degradation products in medical cannabis oil preparations during 3 months of refrigerated storage time were investigated. LCHRMS-Orbitrap(R)and HS-SPME coupled to GC-MS for the investigation of targeted and untargeted cannabinoids, terpenes, and lipid degradation products in Bedrocan(R)and Bediol(R)macerated oils were used as analytical approaches. As regards the cannabinoid trend during 90 days of storage, there were no differences between PhEur-grade olive oil (OOPH) and medium-chain triglycerides oil (MCT oil) coupled to a good stability of preparations for the first 60 days both in Bedrocan(R)and Bediol(R)oils. MCT lipid source extracted a significant concentration of terpenes compared to olive oil. Terpenes showed a different scenario since MCT oil displayed the strongest extraction capacity and conservation trend of all compounds during the shelf life. Terpenes remained stable throughout the entire storage period in MCT formulations while a significant decrease after 15 and 30 days in Bediol(R)and Bedrocan(R)was observed in olive oil. Therefore, MCT oil could be considered a more suitable lipid source compared to olive oil involved in the extraction of medical cannabis for magistral preparations.
cannabis oils; cannabinoids; terpenes; LCHRMS-Orbitrap; HS-SPME-GC; MS; olive oil; MCT oil;
Settore CHIM/08 - Chimica Farmaceutica
lug-2020
Article (author)
File in questo prodotto:
File Dimensione Formato  
2020 molecules_cannabis stability.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 1.12 MB
Formato Adobe PDF
1.12 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/776316
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 11
  • ???jsp.display-item.citation.isi??? 11
social impact