Otitis media (OM) is one of the most common diseases occurring during childhood. Microbiological investigations concerning this topic have been primarily focused on the four classical otopathogens (Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pyogenes) mainly because most of the studies have been conducted with culture-dependent methods. In recent years, the introduction of culture-independent techniques has allowed high-throughput investigation of entire bacterial communities, leading to a better comprehension of the role of resident flora in health and disease. The upper respiratory tract (URT) is a region of major interest in otitis media pathogenesis, as it could serve as a source of pathogens for the middle ear (ME). Studies conducted with culture-independent methods in the URT and ME have provided novel insights on the pathogenesis of middle ear diseases through the identification of both possible new causative agents and of potential protective bacteria, showing that imbalances in bacterial communities could influence the natural history of otitis media in children. The aim of this review is to examine available evidence in microbiome research and otitis media in the pediatric age, with a focus on its different phenotypes: acute otitis media, otitis media with effusion and chronic suppurative otitis media.

Upper Respiratory Tract Microbiome and Otitis Media Intertalk : Lessons from the Literature / F. Folino, L. Ruggiero, P. Capaccio, I. Coro, S. Aliberti, L. Drago, P. Marchisio, S. Torretta. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 9:9(2020 Sep 02), pp. 2845.1-2845.26. [10.3390/jcm9092845]

Upper Respiratory Tract Microbiome and Otitis Media Intertalk : Lessons from the Literature

F. Folino
Primo
Conceptualization
;
P. Capaccio
Conceptualization
;
S. Aliberti
Conceptualization
;
L. Drago
Conceptualization
;
P. Marchisio
Penultimo
Supervision
;
S. Torretta
Ultimo
Supervision
2020-09-02

Abstract

Otitis media (OM) is one of the most common diseases occurring during childhood. Microbiological investigations concerning this topic have been primarily focused on the four classical otopathogens (Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pyogenes) mainly because most of the studies have been conducted with culture-dependent methods. In recent years, the introduction of culture-independent techniques has allowed high-throughput investigation of entire bacterial communities, leading to a better comprehension of the role of resident flora in health and disease. The upper respiratory tract (URT) is a region of major interest in otitis media pathogenesis, as it could serve as a source of pathogens for the middle ear (ME). Studies conducted with culture-independent methods in the URT and ME have provided novel insights on the pathogenesis of middle ear diseases through the identification of both possible new causative agents and of potential protective bacteria, showing that imbalances in bacterial communities could influence the natural history of otitis media in children. The aim of this review is to examine available evidence in microbiome research and otitis media in the pediatric age, with a focus on its different phenotypes: acute otitis media, otitis media with effusion and chronic suppurative otitis media.
adenoid; microbiota; microbiota axes; middle ear; otitis media; upper respiratory tract
Settore MED/38 - Pediatria Generale e Specialistica
Settore MED/10 - Malattie dell'Apparato Respiratorio
Settore MED/31 - Otorinolaringoiatria
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/762817
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