Rationale: Exposure to early life stress (ELS) is known to have pronounced effects on the prefrontal cortex (PFC). However, not all individuals exposed to ELS manifest the same neurobiological and cognitive phenotypes when adults. Dopamine signaling could be a key factor in understanding the effects of stress on PFC-related cognitive function. Objectives: We aimed to investigate the differential effects of ELS on cognitive performance of adult mice and the dopaminergic receptors expression in the PFC. Methods: BALB/c males were exposed to the maternal separation (MS) procedure and their cognitive performance on the eight-arm radial maze (8-RAM) were assessed during adulthood. For molecular-level assessments, we performed mRNA expression analyses for dopamine receptors—DRD1, DRD2, DRD3—and Hers1 expression in the medial PFC. Results: While MS produced an overall impairment on 8-RAM, the stressed animals could be divided in two groups based on their performance: those with impaired cognitive performance (vulnerable to maternal separation, V-MS) and those without any impairment (resilient to maternal separation, R-MS). V-MS animals showed increased DRD1 and DRD2 expression in comparison with other groups. Errors on 8-RAM were also positively correlated with DRD1 and DRD2 mRNA expression. Conclusions: Our findings suggest a potential role of the dopaminergic system in the programming mechanisms of cognitive vulnerability and resilience related to ELS.
Vulnerable and resilient cognitive performance related to early life stress: The potential mediating role of dopaminergic receptors in the medial prefrontal cortex of adult mice / S.G. Tractenberg, R. Orso, K.C. Creutzberg, L.M.C. Malcon, F.S. Lumertz, L.E. Wearick-Silva, T.W. Viola, M.A. Riva, R. Grassi-Oliveira. - In: INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE. - ISSN 0736-5748. - 80:1(2020 Feb 01), pp. 13-27.
|Titolo:||Vulnerable and resilient cognitive performance related to early life stress: The potential mediating role of dopaminergic receptors in the medial prefrontal cortex of adult mice|
RIVA, MARCO ANDREA (Penultimo)
|Parole Chiave:||dopamine; early life stress; maternal separation; resilience; stress; working memory|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||1-feb-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/jdn.10004|
|Appare nelle tipologie:||01 - Articolo su periodico|