This review summarizes the main strategies aimed at the total synthesis of vincamine and congeners. Then, our contribution in this field is presented: we describe (+)-vincamine semi-synthesis using tabersonine as starting material. Characterization and quantification of the main impurities are discussed, and HPLC conditions, structural elucidation and NMR data of four of them are reported.
Vincamine by synthesis and semi-synthesis / E. Bonandi, F. Foschi, C. Marucci, G. Paladino, M. Luzzani, D. Passarella. - In: PHYTOCHEMISTRY REVIEWS. - ISSN 1568-7767. - (2020). [Epub ahead of print] [10.1007/s11101-020-09702-8]
Vincamine by synthesis and semi-synthesis
E. BonandiPrimo
;C. Marucci;G. Paladino;D. Passarella
Ultimo
2020
Abstract
This review summarizes the main strategies aimed at the total synthesis of vincamine and congeners. Then, our contribution in this field is presented: we describe (+)-vincamine semi-synthesis using tabersonine as starting material. Characterization and quantification of the main impurities are discussed, and HPLC conditions, structural elucidation and NMR data of four of them are reported.
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Vincamine Manuscript AIR .pdf
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2020_Article_.pdf
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