Metformin is used for the treatment of type 2 diabetes mellitus and has shown therapeutic effects in preclinical models of other pathologies, such as cancer and autoimmune diseases. The antitumor activity of metformin is due, in part, to immunostimulatory effects. In the context of other pathologies, such as autoimmune or inflammatory diseases, metformin has immunosuppressive effects. There is evidence that the immunostimulatory effects of metformin are indirect. The immunosuppressive effects of metformin in other pathologies appear to be a direct consequence of its action on immune cells. Based on these observations we opine that the pharmacology of metformin is dependent on the pathological context which, to our knowledge, is a novel concept in pharmacology.
Context-Dependent Pharmacological Effects of Metformin on the Immune System / F. Marcucci, E. Romeo, C.A. Caserta, C. Rumio, F. Lefoulon. - In: TRENDS IN PHARMACOLOGICAL SCIENCES. - ISSN 0165-6147. - 41:3(2020 Mar), pp. 162-171.
|Titolo:||Context-Dependent Pharmacological Effects of Metformin on the Immune System|
ROMEO, EUGENIO (Secondo)
RUMIO, CRISTIANO (Penultimo)
|Parole Chiave:||autoimmunity; cancer; immune system; metformin|
|Settore Scientifico Disciplinare:||Settore BIO/16 - Anatomia Umana|
|Data di pubblicazione:||mar-2020|
|Data ahead of print / Data di stampa:||feb-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.tips.2020.01.003|
|Appare nelle tipologie:||01 - Articolo su periodico|