6-Hydroxy-2-methylbenzofuran-4-carboxylic acid was synthesized in two steps, starting from 3,5-dihydroxybenzoate. The product was obtained through a direct thermal one-pot cyclization with propargyl bromide, followed by a base-catalyzed hydrolysis. Its molecular structure was elucidated by means of mono- and bidimensional NMR techniques, ESI-MS, FT-IR and single-crystal X-ray diffraction.
6-Hydroxy-2-methylbenzofuran-4-carboxylic acid / M. Mori, F. Meneghetti, L.R. Chiarelli, A. Diego, D. Nava, A. Gelain, G. Cazzaniga, S. Villa, E.R.E. Pini. - In: MOLBANK. - ISSN 1422-8599. - 2020:2(2020 Jun 18).
6-Hydroxy-2-methylbenzofuran-4-carboxylic acid
M. MoriPrimo
;F. MeneghettiSecondo
;D. Nava;A. Gelain;G. Cazzaniga;S. VillaPenultimo
;E.R.E. Pini
Ultimo
2020
Abstract
6-Hydroxy-2-methylbenzofuran-4-carboxylic acid was synthesized in two steps, starting from 3,5-dihydroxybenzoate. The product was obtained through a direct thermal one-pot cyclization with propargyl bromide, followed by a base-catalyzed hydrolysis. Its molecular structure was elucidated by means of mono- and bidimensional NMR techniques, ESI-MS, FT-IR and single-crystal X-ray diffraction.
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