6-Hydroxy-2-methylbenzofuran-4-carboxylic acid was synthesized in two steps, starting from 3,5-dihydroxybenzoate. The product was obtained through a direct thermal one-pot cyclization with propargyl bromide, followed by a base-catalyzed hydrolysis. Its molecular structure was elucidated by means of mono- and bidimensional NMR techniques, ESI-MS, FT-IR and single-crystal X-ray diffraction.

6-Hydroxy-2-methylbenzofuran-4-carboxylic acid / M. Mori, F. Meneghetti, L.R. Chiarelli, A. Diego, D. Nava, A. Gelain, G. Cazzaniga, S. Villa, E.R.E. Pini. - In: MOLBANK. - ISSN 1422-8599. - 2020:2(2020 Jun 18).

6-Hydroxy-2-methylbenzofuran-4-carboxylic acid

M. Mori
Primo
;
F. Meneghetti
Secondo
;
D. Nava;A. Gelain;G. Cazzaniga;S. Villa
Penultimo
;
E.R.E. Pini
Ultimo
2020-06-18

Abstract

6-Hydroxy-2-methylbenzofuran-4-carboxylic acid was synthesized in two steps, starting from 3,5-dihydroxybenzoate. The product was obtained through a direct thermal one-pot cyclization with propargyl bromide, followed by a base-catalyzed hydrolysis. Its molecular structure was elucidated by means of mono- and bidimensional NMR techniques, ESI-MS, FT-IR and single-crystal X-ray diffraction.
6-hydroxy-2-methylbenzofuran-4-carboxylic acid methyl ester; 6-hydroxy-2-methylbenzofuran-4-carboxylic acid; COSY; NOESY; HSQC; HMBC; XRD;
Settore CHIM/06 - Chimica Organica
Settore CHIM/08 - Chimica Farmaceutica
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/742112
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