Human rotaviruses represent a major cause of severe diarrheal disease in infants and young children. The limited impact of oral vaccines on global estimates of rotavirus mortality and the suboptimal use of oral rehydration justify the need for alternative prophylactic and therapeutic strategies, especially for immunocompromised hosts. The protective effects of colostrum—the first milk produced during the initial 24 to 48 h after parturition—are well documented in the literature. In particular, the ingestion of hyperimmune bovine colostrum has been proposed as an alternative preventive approach against human rotavirus gastroenteritis. Although the immunization of pregnant cows with human rotavirus boosts the release of specific immunoglobulin G in bovine colostrum, it raises regulatory and safety issues. In this study, we demonstrated that the conventional bovine rotavirus vaccine is sufficient to enhance the anti-human rotavirus protective efficacy of bovine colostrum, thus providing a conservative approach to produce hyperimmune bovine colostrum, making it exploitable as a functional food.
Colostrum from cows immunized with a veterinary vaccine against bovine rotavirus displays enhanced in vitro anti-human rotavirus activity / A. Civra, A. Altomare, R. Francese, M. Donalisio, G. Aldini, D. Lembo. - In: JOURNAL OF DAIRY SCIENCE. - ISSN 0022-0302. - 102:6(2019 Jun), pp. 4857-4869.
|Titolo:||Colostrum from cows immunized with a veterinary vaccine against bovine rotavirus displays enhanced in vitro anti-human rotavirus activity|
ALDINI, GIANCARLO (Corresponding)
|Parole Chiave:||colostrum; cows; hyperimmune; immunoglobulins; rotavirus; Animals; Antibodies, Viral; Cattle; Cell Line; Chlorocebus aethiops; Colostrum; Diarrhea; Female; HeLa Cells; Humans; Immunoglobulin G; Pregnancy; Rotavirus; Rotavirus Infections; Rotavirus Vaccines; Vaccination; Vero Cells|
|Settore Scientifico Disciplinare:||Settore CHIM/01 - Chimica Analitica|
Settore CHIM/08 - Chimica Farmaceutica
|Data di pubblicazione:||giu-2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3168/jds.2018-16016|
|Appare nelle tipologie:||01 - Articolo su periodico|