Precisely localizing the sources of brain activity as recorded by EEG is a fundamental procedure and a major challenge for both research and clinical practice. Even though many methods and algorithms have been proposed, their relative advantages and limitations are still not well established. Moreover, these methods involve tuning multiple parameters, for which no principled way of selection exists yet. These uncertainties are emphasized due to the lack of ground-truth for their validation and testing. Here we present the Localize-MI dataset, which constitutes the first open dataset that comprises EEG recorded electrical activity originating from precisely known locations inside the brain of living humans. High-density EEG was recorded as single-pulse biphasic currents were delivered at intensities ranging from 0.1 to 5 mA through stereotactically implanted electrodes in diverse brain regions during pre-surgical evaluation of patients with drug-resistant epilepsy. The uses of this dataset range from the estimation of in vivo tissue conductivity to the development, validation and testing of forward and inverse solution methods.

Simultaneous human intracerebral stimulation and HD-EEG, ground-truth for source localization methods / E. Mikulan, S. Russo, S. Parmigiani, S. Sarasso, F.M. Zauli, A. Rubino, P. Avanzini, A. Cattani, A. Sorrentino, S. Gibbs, F. Cardinale, I. Sartori, L. Nobili, M. Massimini, A. Pigorini. - In: SCIENTIFIC DATA. - ISSN 2052-4463. - 7:1(2020 Dec 01). [10.1038/s41597-020-0467-x]

Simultaneous human intracerebral stimulation and HD-EEG, ground-truth for source localization methods

E. Mikulan
Primo
;
S. Russo
Secondo
;
S. Parmigiani;S. Sarasso;F.M. Zauli;A. Rubino;A. Cattani;M. Massimini
Penultimo
;
A. Pigorini
Ultimo
2020

Abstract

Precisely localizing the sources of brain activity as recorded by EEG is a fundamental procedure and a major challenge for both research and clinical practice. Even though many methods and algorithms have been proposed, their relative advantages and limitations are still not well established. Moreover, these methods involve tuning multiple parameters, for which no principled way of selection exists yet. These uncertainties are emphasized due to the lack of ground-truth for their validation and testing. Here we present the Localize-MI dataset, which constitutes the first open dataset that comprises EEG recorded electrical activity originating from precisely known locations inside the brain of living humans. High-density EEG was recorded as single-pulse biphasic currents were delivered at intensities ranging from 0.1 to 5 mA through stereotactically implanted electrodes in diverse brain regions during pre-surgical evaluation of patients with drug-resistant epilepsy. The uses of this dataset range from the estimation of in vivo tissue conductivity to the development, validation and testing of forward and inverse solution methods.
Settore BIO/09 - Fisiologia
   Human Brain Project Specific Grant Agreement 1 (HBP SGA1)
   HBP SGA1
   EUROPEAN COMMISSION
   H2020
   720270

   Human Brain Project Specific Grant Agreement 2 (HBP SGA2)
   HBP SGA2
   EUROPEAN COMMISSION
   H2020
   785907
1-dic-2020
28-apr-2020
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/732703
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