Depression and anxiety are the most common mood disorders affecting 300 million sufferers worldwide. Maladaptive changes in the neuroendocrine stress response is cited as the most common underlying cause, though how the circuits underlying this response are controlled at the molecular level, remains largely unknown. Approximately 40% of patients do not respond to current treatments, indicating that untapped mechanisms exist. Here we review recent evidence implicating JNK in the control of anxiety and depressive-like behavior with a particular focus on its action in immature granule cells of the hippocampal neurogenic niche and the potential for therapeutic targeting for affective disorders.

JNK regulation of depression and anxiety / P. Hollos, F. Marchisella, E. Coffey. - In: BRAIN PLASTICITY. - ISSN 2213-6312. - 3:2(2018 Aug), pp. 145-155. [10.3233/BPL-170062]

JNK regulation of depression and anxiety

F. Marchisella;
2018

Abstract

Depression and anxiety are the most common mood disorders affecting 300 million sufferers worldwide. Maladaptive changes in the neuroendocrine stress response is cited as the most common underlying cause, though how the circuits underlying this response are controlled at the molecular level, remains largely unknown. Approximately 40% of patients do not respond to current treatments, indicating that untapped mechanisms exist. Here we review recent evidence implicating JNK in the control of anxiety and depressive-like behavior with a particular focus on its action in immature granule cells of the hippocampal neurogenic niche and the potential for therapeutic targeting for affective disorders.
Finnish
JNK; XG-102; JNK1; kinase; anxiety; depression; granule cell; neurogenesis; hippocampus; molecular; mechanism
Settore BIO/11 - Biologia Molecolare
Review essay
Esperti anonimi
Pubblicazione scientifica
ago-2018
IOS press
3
2
145
155
11
Pubblicato
Periodico con rilevanza internazionale
Aderisco
info:eu-repo/semantics/article
JNK regulation of depression and anxiety / P. Hollos, F. Marchisella, E. Coffey. - In: BRAIN PLASTICITY. - ISSN 2213-6312. - 3:2(2018 Aug), pp. 145-155. [10.3233/BPL-170062]
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Article (author)
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P. Hollos, F. Marchisella, E. Coffey
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/730998
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