Lego-inspired capsular devices for the development of personalized dietary supplements : proof of concept with multimodal release of caffeine

Melocchi, A.; Uboldi, M.; Parietti, F.; Cerea, M.; Foppoli, A.; Palugan, L.; Gazzaniga, A.; Maroni, A.; Zema, L.

doi:10.1016/j.xphs.2020.02.013

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Dietary supplement companies have recently started to focus on the personalization of products and the improvement of the relevant performance. In this respect, a versatile, easy-to-handle capsular delivery platform with customizable content and release kinetics was here proposed and evaluated after filling with caffeine as a model dietary ingredient. In particular, capsular devices comprising 1 to 3 independent inner compartments were attained by Lego-inspired assembly of matching modular units with different wall compositions, manufactured by injection molding and fused deposition modeling 3D printing. Accordingly, one-, two- and three-pulse release profiles of the dietary ingredient were obtained from differently assembled devices following the breakup of the compartments occurring promptly (immediate-release), on pH change (delayed-release) or after tunable lag times (pulsatile-release). The latter release mode would enable the onset of the stimulating effect of caffeine at different times of the day after a single administration when convenient. The performance of each individual compartment only depended on the composition (i.e., promptly soluble, swellable/soluble or enteric soluble polymers) and thickness of its own wall, while it was not affected by the composition and number of joined modular units. Moreover, the delivery platform was extended to include an external gastroresistant shell enclosing previously assembled devices.

Lego-inspired capsular devices for the development of personalized dietary supplements : proof of concept with multimodal release of caffeine / A. Melocchi, M. Uboldi, F. Parietti, M. Cerea, A. Foppoli, L. Palugan, A. Gazzaniga, A. Maroni, L. Zema. - In: JOURNAL OF PHARMACEUTICAL SCIENCES. - ISSN 0022-3549. - 109:6(2020 Jun), pp. 1990-1999.

Titolo:	Lego-inspired capsular devices for the development of personalized dietary supplements : proof of concept with multimodal release of caffeine
Autori:	MELOCCHI, ALICE UBOLDI, MARCO Parietti, Federico CEREA, MATTEO FOPPOLI, ANASTASIA ANNA PALUGAN, LUCA GAZZANIGA, ANDREA MARONI, ALESSANDRA (Corresponding) ZEMA, LUCIA mostra contributor esterni nascondi contributor esterni
Parole Chiave:	fused deposition modeling; 3D printing; injection molding; capsular device; oral modified release; thermoplastic polymer
Settore Scientifico Disciplinare:	Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
Data di pubblicazione:	giu-2020
Rivista:	JOURNAL OF PHARMACEUTICAL SCIENCES
Tipologia:	Article (author)
Data ahead of print / Data di stampa:	27-feb-2020
Digital Object Identifier (DOI):	http://dx.doi.org/10.1016/j.xphs.2020.02.013
Appare nelle tipologie:	01 - Articolo su periodico

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Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/2434/728873

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