The genetic variant A1 of bovine b-casein (b-Cn) presents a His residue at a position 67 of the mature protein. This feature makes the Ile66-His67 bond more vulnerable to enzymatic cleavage, determining the release of the peptide b-Cn f(60–66), named b-casomorphin 7 (BCM7). BCM7 is an opioid-agonist for μ receptors, and it has been hypothesized to be involved in the development of different non-transmissible diseases in humans. In the last decade, studies have provided additional results on the potential health impact of b-Cn A1 and BCM7. These studies, here reviewed, highlighted a relation between the consumption of b-Cn A1 (and its derivative BCM7) and the increase of inflammatory response as well as discomfort at the gastrointestinal level. Conversely, the role of BCM7 and the effects of ingestion of b-Cn A1 on the onset or worsening of other nontransmissible diseases as caused or favored by still need proof of evidence. Overall, the reviewed literature demonstrates that the “b-Cn A1/BCM7 issue” remains an intriguing but not exhaustively explained topic in human nutrition. On this basis, policies in favor of breeding for b-Cn variants not releasing BCM7 and consumption of “A1-like” milk appear not yet sound for a healthier and safer nutrition.
Occurrence, biological properties and potential effects on human health of β-casomorphin 7 : Current knowledge and concerns / A. Summer, F. Di Frangia, P. Ajmone Marsan, I. De Noni, M. Malacarne. - In: CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION. - ISSN 1040-8398. - (2020 Feb 07). [Epub ahead of print] [10.1080/10408398.2019.1707157]
Occurrence, biological properties and potential effects on human health of β-casomorphin 7 : Current knowledge and concerns
I. De Noni
Penultimo
;
2020
Abstract
The genetic variant A1 of bovine b-casein (b-Cn) presents a His residue at a position 67 of the mature protein. This feature makes the Ile66-His67 bond more vulnerable to enzymatic cleavage, determining the release of the peptide b-Cn f(60–66), named b-casomorphin 7 (BCM7). BCM7 is an opioid-agonist for μ receptors, and it has been hypothesized to be involved in the development of different non-transmissible diseases in humans. In the last decade, studies have provided additional results on the potential health impact of b-Cn A1 and BCM7. These studies, here reviewed, highlighted a relation between the consumption of b-Cn A1 (and its derivative BCM7) and the increase of inflammatory response as well as discomfort at the gastrointestinal level. Conversely, the role of BCM7 and the effects of ingestion of b-Cn A1 on the onset or worsening of other nontransmissible diseases as caused or favored by still need proof of evidence. Overall, the reviewed literature demonstrates that the “b-Cn A1/BCM7 issue” remains an intriguing but not exhaustively explained topic in human nutrition. On this basis, policies in favor of breeding for b-Cn variants not releasing BCM7 and consumption of “A1-like” milk appear not yet sound for a healthier and safer nutrition.File | Dimensione | Formato | |
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Summer__DeNoni_et_al(2020)_BCM7_Curr knowledge and concerns_CRFSN.pdf
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