SMYD3 is a member of the SMYD lysine methylase family and plays an important role in the methylation of various histone and non-histone targets. Aberrant SMYD3 expression contributes to carcinogenesis and SMYD3 upregulation was proposed as a prognostic marker in various solid cancers. Here we summarize SMYD3-mediated regulatory mechanisms, which are implicated in the pathophysiology of cancer, as drivers of distinct oncogenic pathways. We describe SMYD3-dependent mechanisms affecting cancer progression, highlighting SMYD3 interplay with proteins and RNAs involved in the regulation of cancer cell proliferation, migration and invasion. We also address the effectiveness and mechanisms of action for the currently available SMYD3 inhibitors. The findings analyzed herein demonstrate that a complex network of SMYD3-mediated cytoplasmic and nuclear interactions promote oncogenesis across different cancer types. These evidences depict SMYD3 as a modulator of the transcriptional response and of key signaling pathways, orchestrating multiple oncogenic inputs and ultimately, promoting transcriptional reprogramming and tumor transformation. Further insights into the oncogenic role of SMYD3 and its targeting of different synergistic oncogenic signals may be beneficial for effective cancer treatment.
SMYD3: An Oncogenic Driver Targeting Epigenetic Regulation and Signaling Pathways / G. Caretti, C. Bottino, A. Peserico, C. Simone. - In: CANCERS. - ISSN 2072-6694. - 12:1(2020 Jan 01).
|Titolo:||SMYD3: An Oncogenic Driver Targeting Epigenetic Regulation and Signaling Pathways|
CARETTI, GIUSEPPINA (Ultimo) (Corresponding)
BOTTINO, CINZIA (Primo)
|Parole Chiave:||KMT; SMYD3; epigenetic inhibitors; lysine methylation.|
|Settore Scientifico Disciplinare:||Settore BIO/18 - Genetica|
|Data di pubblicazione:||1-gen-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/cancers12010142|
|Appare nelle tipologie:||01 - Articolo su periodico|