Macrophages undergo a wide spectrum of polarized activation states, and have the potential both to elicit tumor and tissue destructive reactions and to promote tumor progression (macrophage balance). In general, tumor-associated macrophages (TAM) from established tumors and the related myeloid-derived suppressor cells are diverse and have properties of M2-activated cells. As such, they help cancer progression and metastasis. Therefore, TAM are a key component of pathways connecting inflammation and cancer.

Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation / A. Mantovani, A. Sica, P. Allavena, C. Garlanda, M. Locati. - In: HUMAN IMMUNOLOGY. - ISSN 0198-8859. - 70:5(2009 May), pp. 325-330. [10.1016/j.humimm.2009.02.008]

Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation

A. Mantovani
Primo
;
M. Locati
Ultimo
2009

Abstract

Macrophages undergo a wide spectrum of polarized activation states, and have the potential both to elicit tumor and tissue destructive reactions and to promote tumor progression (macrophage balance). In general, tumor-associated macrophages (TAM) from established tumors and the related myeloid-derived suppressor cells are diverse and have properties of M2-activated cells. As such, they help cancer progression and metastasis. Therefore, TAM are a key component of pathways connecting inflammation and cancer.
Cancer; Cancer-related inflammation; Cytokines; Inflammation; Macrophages; Monocytes; Myeloid-derived suppressor cells; Polarization
Settore MED/04 - Patologia Generale
mag-2009
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/70552
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