The antimicrobial activity represents a cornerstone in the development of biomaterials: it is a leading request in many areas, including biology, medicine, environment and industry. Over the years, different polymeric scaffolds are proposed as solutions, based on the encapsulation of metal ions/particles, antibacterial agents or antibiotics. However, the compliance with the biocompatibility criteria and the concentration of the active principles to avoid under- and over-dosing are being debated. In this work, we propose the synthesis of a versatile hydrogel using branched polyacrylic acid (carbomer 974P) and aliphatic polyetherdiamine (elastamine®) through physico-chemical transition, able to show its ability to counteract the bacterial growth and infections thanks to the polymers used, that are not subjected to further chemical modifications. In particular, the antimicrobial activity is clearly demonstrated against Staphyloccoccus aureus and Candida albicans, two well-known opportunistic pathogens. Moreover, we discuss the hydrogel use as drug carrier to design a unique device able to combine the antibacterial/antimicrobial properties to the controlled drug delivery, as a promising tool for a wide range of biomedical applications.
Design of polymer-based antimicrobial hydrogels through physico-chemical transition / E. Mauri, D. Naso, A. Rossetti, E. Borghi, E. Ottaviano, G. Griffini, M. Masi, A. Sacchetti, F. Rossi. - In: MATERIALS SCIENCE AND ENGINEERING. C, BIOMIMETIC MATERIALS, SENSORS AND SYSTEMS. - ISSN 0928-4931. - 103(2019 Oct).
|Titolo:||Design of polymer-based antimicrobial hydrogels through physico-chemical transition|
|Parole Chiave:||Antimicrobial; Drug delivery; Hydrogels; Polymer; Rheology; Acrylic Resins; Anti-Infective Agents; Candida albicans; Drug Carriers; Drug Liberation; Hydrogels; Polymers; Rheology; Staphylococcus aureus|
|Settore Scientifico Disciplinare:||Settore CHIM/07 - Fondamenti Chimici delle Tecnologie|
Settore ING-IND/23 - Chimica Fisica Applicata
Settore MED/07 - Microbiologia e Microbiologia Clinica
|Data di pubblicazione:||ott-2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.msec.2019.109791|
|Appare nelle tipologie:||01 - Articolo su periodico|