A study was undertaken to determine the cardioprotective effects of parrodienes prepared from the feather pigments of parrots (Ara macao). Adult male Sprague-Dawley rats were divided into three experimental groups and perfused with KHB buffer with or without treatment of 2,4,6-octatrienal (1) (50 mM) or its potassium salt (2) (50 mM). All hearts were then subjected to 30 min ischemia followed by a 2 h reperfusion. Ischemia/reperfusion resulted in a significant amount of tissue injury, cardiomyocyte apoptosis, and depression in hemodynamic functions. Parrodiene treatment prevented the development of myocardial injury after ischemia/reperfusion. Western blot analysis indicated that 1 and 2 reduced the oxidative stress, induced the expression of Bcl-2, and caused increased phosphorylation of Akt. These agents also reduced myocardial ischemic reperfusion injury presumably by reducing oxidative stress and activating the survival signal through the Akt-Bcl-2 pathway.
Cardioprotection with the Parrodiene 2,4,6-Octatrienal and Its Potassium Salt through Activation of the Akt-Bcl-2 Survival Pathway / S. Mukherjee, D. Ray, M. Falchi, A. Bertelli, E. Pini, D.K. Das. - In: JOURNAL OF NATURAL PRODUCTS. - ISSN 0163-3864. - 72:5(2009), pp. 871-875.
|Titolo:||Cardioprotection with the Parrodiene 2,4,6-Octatrienal and Its Potassium Salt through Activation of the Akt-Bcl-2 Survival Pathway|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
Settore CHIM/06 - Chimica Organica
|Data di pubblicazione:||2009|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1021/np800444a|
|Appare nelle tipologie:||01 - Articolo su periodico|