Stem cells have received an increasing attention by the scientific community for their potential applications in regenerative medicine. In recent years, a new approach has surfaced, which is the possibility of re-programming somatic cells (adult cells) into stem-cell-like progenitors. In fact, a growing body of evidence suggests that lineage-restricted somatic cells are capable of gaining increased plasticity, comparable to that of stem cells. Along this line, a synthetic purine, reversine, has been shown to increase cell plasticity of differentiated cells, including murine myoblasts and human dermal fibroblasts (1, 2). Moreover, initial results seem to point out that reversine may also increase cell plasticity of adult stem cells, that often can be induced to differentiate into the desired cell types with yields that are too low to be practical for their therapeutic use. Herein we show that reversine treatment improves the differentiation capability of dermal fibroblasts, mesoangioblasts, and mesenchymal stem cells. [1] Anastasia L., Sampaolesi M, et al. Cell Death Differ. 2006, 12, 2042-51. [2] Fania, C, Anastasia L, et al. Electrophoresis. 2009 Jun;30(12):2193-206.

A small synthetic purine, reversine, increase cell plasticity of differentiated cells and of adult stem cells / E. Conforti, E. Arrigoni, M. Piccoli, L. de Girolamo, B. Venerando, G. Tettamanti, A.T. Brini, L. Anastasia. ((Intervento presentato al 54. convegno National Meeting of the Italian Society of Biochemistry and Molecular Biology (SIB) tenutosi a Catania nel 2009.

A small synthetic purine, reversine, increase cell plasticity of differentiated cells and of adult stem cells

E. Arrigoni
Secondo
;
L. de Girolamo;B. Venerando;G. Tettamanti;A.T. Brini
Penultimo
;
L. Anastasia
Ultimo
2009-09

Abstract

Stem cells have received an increasing attention by the scientific community for their potential applications in regenerative medicine. In recent years, a new approach has surfaced, which is the possibility of re-programming somatic cells (adult cells) into stem-cell-like progenitors. In fact, a growing body of evidence suggests that lineage-restricted somatic cells are capable of gaining increased plasticity, comparable to that of stem cells. Along this line, a synthetic purine, reversine, has been shown to increase cell plasticity of differentiated cells, including murine myoblasts and human dermal fibroblasts (1, 2). Moreover, initial results seem to point out that reversine may also increase cell plasticity of adult stem cells, that often can be induced to differentiate into the desired cell types with yields that are too low to be practical for their therapeutic use. Herein we show that reversine treatment improves the differentiation capability of dermal fibroblasts, mesoangioblasts, and mesenchymal stem cells. [1] Anastasia L., Sampaolesi M, et al. Cell Death Differ. 2006, 12, 2042-51. [2] Fania, C, Anastasia L, et al. Electrophoresis. 2009 Jun;30(12):2193-206.
Settore BIO/10 - Biochimica
Settore BIO/14 - Farmacologia
Società Italiana di Biochimica e Biologia Molecolare
A small synthetic purine, reversine, increase cell plasticity of differentiated cells and of adult stem cells / E. Conforti, E. Arrigoni, M. Piccoli, L. de Girolamo, B. Venerando, G. Tettamanti, A.T. Brini, L. Anastasia. ((Intervento presentato al 54. convegno National Meeting of the Italian Society of Biochemistry and Molecular Biology (SIB) tenutosi a Catania nel 2009.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/69408
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