PURPOSE: To assess the possible cognitive alterations in epilepsy patients compared with controls over 5 years, and to investigate the clinical variables mainly implied in mental impairment. METHODS: In our longitudinal single-center study, 50 patients with temporal lobe epilepsy (TLE) and 50 controls were administered the same battery of comprehensive neuropsychological tests at baseline and after 5 years. RESULTS: TLE patients showed a significant impairment in attention and psychomotor speed compared with controls after 5 years, while the other cognitive domains did not exhibit any important changes. This worsening was mainly related to the duration of epilepsy, the age at onset, a history of tonic-clonic seizures and a low educational level. CONCLUSIONS: We believe that tapping the attention and psychomotor speed decline in TLE patients should be considered relevant for future research, in order to achieve a deeper understanding of the cognitive dimensions of this field

Attention and psychomotor speed decline in patients with temporal lobe epilepsy : a longitudinal study / A. Piazzini, K. Turner, R. Chifari, A. Morabito, R. Canger, M.P. Canevini. - In: EPILEPSY RESEARCH. - ISSN 0920-1211. - 72:2-3(2006 Dec), pp. 89-96. [10.1016/j.eplepsyres.2006.04.004]

Attention and psychomotor speed decline in patients with temporal lobe epilepsy : a longitudinal study

K. Turner;A. Morabito;R. Canger;M.P. Canevini
2006-12

Abstract

PURPOSE: To assess the possible cognitive alterations in epilepsy patients compared with controls over 5 years, and to investigate the clinical variables mainly implied in mental impairment. METHODS: In our longitudinal single-center study, 50 patients with temporal lobe epilepsy (TLE) and 50 controls were administered the same battery of comprehensive neuropsychological tests at baseline and after 5 years. RESULTS: TLE patients showed a significant impairment in attention and psychomotor speed compared with controls after 5 years, while the other cognitive domains did not exhibit any important changes. This worsening was mainly related to the duration of epilepsy, the age at onset, a history of tonic-clonic seizures and a low educational level. CONCLUSIONS: We believe that tapping the attention and psychomotor speed decline in TLE patients should be considered relevant for future research, in order to achieve a deeper understanding of the cognitive dimensions of this field
Cognitive function; Deterioration; Temporal lobe epilepsy
Settore MED/26 - Neurologia
Settore MED/01 - Statistica Medica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/68414
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