Although many details remain still elusive, it became increasingly evident in recent years that mechanosensing of microenvironmental biophysical cues and subsequent mechanotransduction are strongly involved in the regulation of neuronal cell development and functioning. This review gives an overview about the current understanding of brain and neuronal cell mechanobiology and how it impacts on neurogenesis, neuronal migration, differentiation, and maturation. We will focus particularly on the events in the cell/microenvironment interface and the decisive extracellular matrix (ECM) parameters (i.e. rigidity and nanometric spatial organisation of adhesion sites) that modulate integrin adhesion complex-based mechanosensing and mechanotransductive signalling. It will also be outlined how biomaterial approaches mimicking essential ECM features help to understand these processes and how they can be used to control and guide neuronal cell behaviour by providing appropriate biophysical cues. In addition, principal biophysical methods will be highlighted that have been crucial for the study of neuronal mechanobiology.

Mechanotransduction in neuronal cell development and functioning / M. Chighizola, T. Dini, C. Lenardi, P. Milani, A. Podestà, C. Schulte. - In: BIOPHYSICAL REVIEWS. - ISSN 1867-2450. - 11:5(2019 Oct 15), pp. 701-720. [10.1007/s12551-019-00587-2]

Mechanotransduction in neuronal cell development and functioning

M. Chighizola;C. Lenardi;P. Milani;A. Podestà;C. Schulte
2019-10-15

Abstract

Although many details remain still elusive, it became increasingly evident in recent years that mechanosensing of microenvironmental biophysical cues and subsequent mechanotransduction are strongly involved in the regulation of neuronal cell development and functioning. This review gives an overview about the current understanding of brain and neuronal cell mechanobiology and how it impacts on neurogenesis, neuronal migration, differentiation, and maturation. We will focus particularly on the events in the cell/microenvironment interface and the decisive extracellular matrix (ECM) parameters (i.e. rigidity and nanometric spatial organisation of adhesion sites) that modulate integrin adhesion complex-based mechanosensing and mechanotransductive signalling. It will also be outlined how biomaterial approaches mimicking essential ECM features help to understand these processes and how they can be used to control and guide neuronal cell behaviour by providing appropriate biophysical cues. In addition, principal biophysical methods will be highlighted that have been crucial for the study of neuronal mechanobiology.
Bioengineering; Biomaterials; Biophysics; Mechanobiology; Neuronal differentiation
Settore BIO/13 - Biologia Applicata
Settore BIO/11 - Biologia Molecolare
15-ott-2019
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/683347
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