IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca

IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Milano.

AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.

Currently available prognostic scoring systems in primary myelofibrosis (PMF) do not integrate clinical, histological, and molecular data, or they also required information on “other” mutations that are available in the clinical practice only in a very limited number of laboratories. In the present multicenter study, including 401 PMF patients, an integrated International Prognostic Scoring System (I-IPSS) was developed by combining IPSS, grade of bone marrow fibrosis (GBMF), and driver mutations molecular status (MS) to define PMF prognosis at diagnosis. Four prognostic categories were identified: I-IPSS–low risk (113 patients), I-IPSS–intermediate-1 risk (56 patients), I-IPSS–intermediate-2 risk (154 patients), and I-IPSS–high risk (78 patients). Median overall survival was 26.7 years in I-IPSS–intermediate-1, 10.8 in I-IPSS–intermediate-2, and 6.4 in I-IPSS-high-risk patients (log-rank test <0.0001); instead, it was not reached in the I-IPSS–low-risk cohort because of the extremely low number of registered deaths. The addition of GBMF and MS to IPSS improved the efficacy for predicting the risk of death. Indeed, the sensitivity of I-IPSS was significantly higher (P <.05) than that of IPSS, considering both total deaths and 5- and 10-year mortality. This comprehensive approach allows clinicians to evaluate mutual interactions between IPSS, GBMF, and MS and identify high-risk patients with poor prognosis who may benefit from aggressive treatments. More importantly, this integrated score can be easily applicable worldwide as it only required information that represent the good clinical practice in the management of PMF patients.

Integrating clinical, morphological, and molecular data to assess prognosis in patients with primary myelofibrosis at diagnosis : a practical approach / A. Iurlo, E.M. Elli, F. Palandri, D. Cattaneo, A. Bossi, I. Cortinovis, C. Bucelli, N. Orofino, F. Brioschi, G. Auteri, P. Bianchi, S. Fabris, G. Isimbaldi, E. Sabattini, L. Baldini, U. Gianelli. - In: HEMATOLOGICAL ONCOLOGY. - ISSN 0278-0232. - 37:4(2019 Oct), pp. 424-433.

Powered by IRIS-about IRIS-Utilizzo dei cookie

 Copyright © 2020