Recent evidence indicates a possible role of D-dimer in the early diagnosis of ischemic stroke subtypes. Whether D-dimer can also predict the long-term outcome following ischemic stroke is controversial. To define the prognostic role of D-dimer, patients hospitalized after an acute ischemic cerebrovascular event underwent D-dimer measurement (Liatest D-D; normal level < 0.50 mu g/ml) on admission and were followed up for recurrent cerebrovascular events, occurrence of other cardiovascular events, and mortality. We enrolled 96 patients (mean age 74.9 years, 42 men). Mean follow-up was 61.5 months; 47 (48.5%) patients died, 23 (48.9%) because of a vascular event. There was no difference in mean D-dimer levels between dead patients and survivors (1.68 and 1.63 mu g/ml, P= NS), but the mortality risk was higher with D-dimer of at least 0.50 mu g/ml (odds ratio, 5.32; 95% confidence interval, 1.79-15.84). After adjustment for age and stroke subtype, the odds ratio was not significant. Mean D-dimer was similar between patients with and without a new vascular event (1.43 and 1.68 mu g/ml, P= NS), and D-dimer of at least 0.50 mu g/ml was not predictive of an increased risk of subsequent events. D-dimer levels measured in the acute phase after an acute cerebrovascular event probably do not predict the long-term clinical outcome.
D-dimer is not a long-term prognostic marker following acute cerebral ischemia / A. Squizzato, W. Ageno, S. Finazzi, V. Mera, E. Romualdi, A. Bossi, A. Venco. - In: BLOOD COAGULATION & FIBRINOLYSIS. - ISSN 0957-5235. - 17:4(2006 Jun), pp. 303-306.
|Titolo:||D-dimer is not a long-term prognostic marker following acute cerebral ischemia|
BOSSI, ANNA (Penultimo)
|Parole Chiave:||D-dimer; Prognosis; Stroke|
|Settore Scientifico Disciplinare:||Settore MED/01 - Statistica Medica|
|Data di pubblicazione:||giu-2006|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1097/01.mbc.0000224850.57872.d0|
|Appare nelle tipologie:||01 - Articolo su periodico|