PURPOSE: The aim of this study was to evaluate the long-term cognitive outcome in children with continuous spikes and waves during slow wave sleep (CSWS syndrome). METHODS: We reviewed the neuropsychological tests of 25 children diagnosed with CSWS between 1987 and 2010 and with a mean follow-up of 13.5 years. KEY FINDINGS: Cognitive performances worsened during CSWS in virtually all patients. Seven patients (28%) with nonlesional epilepsy had a positive outcome; three patients (12%) showed persistence of motor deficit without involvement of cognitive functions; and seven patients (28%) who presented a long duration of CSWS (mean = 28.1 months) had a negative cognitive outcome. In 6 patients (24%) with structural or metabolic disorders before CSWS onset cognitive outcomes did not change; 2 patients (8%) had a negative outcome irrespective of the duration or presence of other neurologic disorders before CSWS onset. Forty-four percent of children with CSWS demonstrated permanent cognitive impairment. SIGNIFICANCE: The long-term outcome of CSWS syndrome is variable and seems to depend on treatment response, disease duration, and underlying etiology.
Long-term evolution of neuropsychological competences in encephalopathy with status epilepticus during sleep : a variable prognosis / M. Pera, D. Brazzo, N. Altieri, U. Balottin, P. Veggiotti. - In: EPILEPSIA. - ISSN 0013-9580. - 54:suppl. 7(2013), pp. 77-85.
Long-term evolution of neuropsychological competences in encephalopathy with status epilepticus during sleep : a variable prognosis
P. Veggiotti
2013
Abstract
PURPOSE: The aim of this study was to evaluate the long-term cognitive outcome in children with continuous spikes and waves during slow wave sleep (CSWS syndrome). METHODS: We reviewed the neuropsychological tests of 25 children diagnosed with CSWS between 1987 and 2010 and with a mean follow-up of 13.5 years. KEY FINDINGS: Cognitive performances worsened during CSWS in virtually all patients. Seven patients (28%) with nonlesional epilepsy had a positive outcome; three patients (12%) showed persistence of motor deficit without involvement of cognitive functions; and seven patients (28%) who presented a long duration of CSWS (mean = 28.1 months) had a negative cognitive outcome. In 6 patients (24%) with structural or metabolic disorders before CSWS onset cognitive outcomes did not change; 2 patients (8%) had a negative outcome irrespective of the duration or presence of other neurologic disorders before CSWS onset. Forty-four percent of children with CSWS demonstrated permanent cognitive impairment. SIGNIFICANCE: The long-term outcome of CSWS syndrome is variable and seems to depend on treatment response, disease duration, and underlying etiology.File | Dimensione | Formato | |
---|---|---|---|
follow up ESES.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
415.6 kB
Formato
Adobe PDF
|
415.6 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.