The generation of different cell types from stem cells containing identical genetic information and their organization into tissues and organs during development is a highly complex process that requires defined transcriptional programs. Maintenance of such programs is epigenetically regulated and the factors involved in these processes are often essential for development. The activities required for cell-fate decisions are frequently deregulated in human tumors, and the elucidation of the molecular mechanisms that regulate these processes is therefore important for understanding both developmental processes and tumorigenesis.
Regulation of stem cell differentiation by histone methyltransferases and demethylases / D. Pasini, .P. Bracken Adrian, K. Agger, J. Christensen, K. Hansen, P.A.C. Cloos, K. Helin. - In: COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY. - ISSN 0091-7451. - 73(2008), pp. 253-263. ((Intervento presentato al 73. convegno Cold Spring Harbor Symposium on Quantitative Biology tenutosi a Cold Spring Harbor nel 2008.
Regulation of stem cell differentiation by histone methyltransferases and demethylases
D. PasiniPrimo
;
2008
Abstract
The generation of different cell types from stem cells containing identical genetic information and their organization into tissues and organs during development is a highly complex process that requires defined transcriptional programs. Maintenance of such programs is epigenetically regulated and the factors involved in these processes are often essential for development. The activities required for cell-fate decisions are frequently deregulated in human tumors, and the elucidation of the molecular mechanisms that regulate these processes is therefore important for understanding both developmental processes and tumorigenesis.File | Dimensione | Formato | |
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