Epigenetic deregulation of gene expression is emerging as key mechanism in tumorigenesis. Deregulated activity of the chromatin remodeling Polycomb Repressive Complex 2 (PRC2) has recently been shown to be a frequent event in human tumors. Here we discuss these findings and speculate on the role of the PRC2 complex in controlling gene expression during normal cellular proliferation and cancer development.
Polycomb group proteins in cell cycle progression and cancer / D. Pasini, P. Bracken Adrian, K. Helin. - In: CELL CYCLE. - ISSN 1538-4101. - 3:4(2004), pp. 396-400.
Polycomb group proteins in cell cycle progression and cancer
D. PasiniPrimo
;
2004
Abstract
Epigenetic deregulation of gene expression is emerging as key mechanism in tumorigenesis. Deregulated activity of the chromatin remodeling Polycomb Repressive Complex 2 (PRC2) has recently been shown to be a frequent event in human tumors. Here we discuss these findings and speculate on the role of the PRC2 complex in controlling gene expression during normal cellular proliferation and cancer development.
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