The α7 nicotinic acetylcholine receptor (CHRNA7)modulates the inflammatory response by activating the cholinergic anti-inflammatory pathway. CHRFAM7A, the human-restricted duplicated form of CHRNA7, has a negative effect on the functioning of α7 receptors, suggesting that CHRFAM7A expression regulation may be a key step in the modulation of inflammation in the human setting. The analysis of the CHRFAM7A gene's regulatory region reveals some of the mechanisms driving its expression and responsiveness to LPS in human immune cell models. Moreover, given the immunomodulatory potential of donepezil we show that it differently modulates CHRFAM7A and CHRNA7 responsiveness to LPS, thus contributing to its therapeutic potential.

Effect of donepezil on the expression and responsiveness to LPS of CHRNA7 and CHRFAM7A in macrophages : a possible link to the cholinergic anti-inflammatory pathway / A. Maroli, S. Di Lascio, L. Drufuca, S. Cardani, E. Setten, M. Locati, D. Fornasari, R. Benfante. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 332(2019), pp. 155-166.

Effect of donepezil on the expression and responsiveness to LPS of CHRNA7 and CHRFAM7A in macrophages : a possible link to the cholinergic anti-inflammatory pathway

S. Di Lascio;L. Drufuca;S. Cardani;E. Setten;M. Locati;D. Fornasari;
2019

Abstract

The α7 nicotinic acetylcholine receptor (CHRNA7)modulates the inflammatory response by activating the cholinergic anti-inflammatory pathway. CHRFAM7A, the human-restricted duplicated form of CHRNA7, has a negative effect on the functioning of α7 receptors, suggesting that CHRFAM7A expression regulation may be a key step in the modulation of inflammation in the human setting. The analysis of the CHRFAM7A gene's regulatory region reveals some of the mechanisms driving its expression and responsiveness to LPS in human immune cell models. Moreover, given the immunomodulatory potential of donepezil we show that it differently modulates CHRFAM7A and CHRNA7 responsiveness to LPS, thus contributing to its therapeutic potential.
Cholinergic anti-inflammatory pathway; CHRFAM7A; CHRNA7; Donepezil; LPS; Transcription
Settore BIO/14 - Farmacologia
Settore MED/04 - Patologia Generale
2019
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/659606
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