The α7 nicotinic acetylcholine receptor (CHRNA7)modulates the inflammatory response by activating the cholinergic anti-inflammatory pathway. CHRFAM7A, the human-restricted duplicated form of CHRNA7, has a negative effect on the functioning of α7 receptors, suggesting that CHRFAM7A expression regulation may be a key step in the modulation of inflammation in the human setting. The analysis of the CHRFAM7A gene's regulatory region reveals some of the mechanisms driving its expression and responsiveness to LPS in human immune cell models. Moreover, given the immunomodulatory potential of donepezil we show that it differently modulates CHRFAM7A and CHRNA7 responsiveness to LPS, thus contributing to its therapeutic potential.
Effect of donepezil on the expression and responsiveness to LPS of CHRNA7 and CHRFAM7A in macrophages : a possible link to the cholinergic anti-inflammatory pathway / A. Maroli, S. Di Lascio, L. Drufuca, S. Cardani, E. Setten, M. Locati, D. Fornasari, R. Benfante. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 332(2019), pp. 155-166.
Titolo: | Effect of donepezil on the expression and responsiveness to LPS of CHRNA7 and CHRFAM7A in macrophages : a possible link to the cholinergic anti-inflammatory pathway |
Autori: | |
Parole Chiave: | Cholinergic anti-inflammatory pathway; CHRFAM7A; CHRNA7; Donepezil; LPS; Transcription |
Settore Scientifico Disciplinare: | Settore BIO/14 - Farmacologia Settore MED/04 - Patologia Generale |
Data di pubblicazione: | 2019 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.jneuroim.2019.04.012 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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