The widespread exchange of genes between bacteria must have consequences on the global architecture of their genomes, which are being found in the abundant genomic data available today. Most of the expansion of bacterial protein families can be attributed to transfer events, which are positively biased for smaller evolutionary distances between genomes, and more frequent for classes that are larger, when summed over all known bacteria. Moreover, "innovation" events where horizontal transfers carry exogenous evolutionary families appear to be less frequent for larger genomes. This dynamic expansion of evolutionary families is interconnected with the acquisition of new biological functions and thus with the size and distribution of the genes' functional categories found on a genome. This commentary presents our recent contributions to this line of work and possible future directions.

Large-scale dynamics of horizontal transfers / L. Grassi, J. Grilli, M. Cosentino Lagomarsino. - In: MOBILE GENETIC ELEMENTS. - ISSN 2159-256X. - 2:3(2012 May), pp. 163-167. [10.4161/mge.21112]

Large-scale dynamics of horizontal transfers

Cosentino Lagomarsino, Marco
2012-05

Abstract

The widespread exchange of genes between bacteria must have consequences on the global architecture of their genomes, which are being found in the abundant genomic data available today. Most of the expansion of bacterial protein families can be attributed to transfer events, which are positively biased for smaller evolutionary distances between genomes, and more frequent for classes that are larger, when summed over all known bacteria. Moreover, "innovation" events where horizontal transfers carry exogenous evolutionary families appear to be less frequent for larger genomes. This dynamic expansion of evolutionary families is interconnected with the acquisition of new biological functions and thus with the size and distribution of the genes' functional categories found on a genome. This commentary presents our recent contributions to this line of work and possible future directions.
evolution; gene families; genome innovation; genomics; horizontal transfers
Settore BIO/18 - Genetica
Settore FIS/02 - Fisica Teorica, Modelli e Metodi Matematici
MOBILE GENETIC ELEMENTS
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/657996
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact