Thanks to a highly active catalyst, the scope of the (cyclopentadienone)iron complex-promoted ‘hydrogen-borrowing’ (HB) amination has been expanded to secondary alcohols, which had previously been reported to react only in the presence of large amounts of co-catalysts. A range of cyclic and acyclic secondary alcohols were reacted with aromatic and aliphatic amines giving fair to excellent yields of the substitution products. The catalyst was also able to promote the cyclization of diols bearing a secondary alcohol group with primary amines to generate saturated N-heterocycles.

Hydrogen-Borrowing Amination of Secondary Alcohols Promoted by a (Cyclopentadienone)iron Complex / X. Bai, F. Aiolfi, M. Cettolin, U. Piarulli, A. DAL CORSO, L.L. Pignataro, C.M.A. Gennari. - In: SYNTHESIS. - ISSN 0039-7881. - 51:18(2019), pp. 3545-3555. [10.1055/s-0039-1690101]

Hydrogen-Borrowing Amination of Secondary Alcohols Promoted by a (Cyclopentadienone)iron Complex

X. Bai
Primo
;
M. Cettolin;A. DAL CORSO;L.L. Pignataro
Penultimo
;
C.M.A. Gennari
Ultimo
2019

Abstract

Thanks to a highly active catalyst, the scope of the (cyclopentadienone)iron complex-promoted ‘hydrogen-borrowing’ (HB) amination has been expanded to secondary alcohols, which had previously been reported to react only in the presence of large amounts of co-catalysts. A range of cyclic and acyclic secondary alcohols were reacted with aromatic and aliphatic amines giving fair to excellent yields of the substitution products. The catalyst was also able to promote the cyclization of diols bearing a secondary alcohol group with primary amines to generate saturated N-heterocycles.
hydrogen borrowing; iron; amination; alcohol; (cyclopentadienone)iron complexes
Settore CHIM/06 - Chimica Organica
2019
26-giu-2019
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0039-1690101
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/652003
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