We evaluated the acute effect of the application of positive end-expiratory pressure (PEEP) on LV diastolic function in 10 healthy subjects. We assessed load dependent diastolic function by Doppler examination of transmitral flow and load independent diastolic function by color M-mode propagation velocity of early flow into the LV cavity (Vp). During the application of PEEP in comparison to the baseline, we found a significant reduction of the E wave peak velocity [79 (64-83) vs. 65 (57-72) cm/s; p = 0.028] and a significant reduction in Vp [84 (73-97) vs. 53 (48-66); p = 0.012]. Moreover, we found a significant reduction in left atrial area [15 (13-18) vs. 12 (10-14) cm2; p = 0.018] and right atrial area [12 (11-15) vs. 11 (9-12) cm2; p = 0.015]. No difference was found in global LV systolic function. The application of PEEP acutely modifies the diastolic flow pattern across the mitral valve, and reduces atrial dimensions.

Acute effects of positive end-expiratory pressure on left ventricle diastolic function in healthy subjects / A. Maestroni, S. Aliberti, O. Amir, G. Milani, A.M. Brambilla, F. Piffer, F. Tardini, R. Cosentini. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1828-0447. - 4:3(2009), pp. 249-254.

Acute effects of positive end-expiratory pressure on left ventricle diastolic function in healthy subjects

S. Aliberti
Secondo
;
F. Piffer;
2009

Abstract

We evaluated the acute effect of the application of positive end-expiratory pressure (PEEP) on LV diastolic function in 10 healthy subjects. We assessed load dependent diastolic function by Doppler examination of transmitral flow and load independent diastolic function by color M-mode propagation velocity of early flow into the LV cavity (Vp). During the application of PEEP in comparison to the baseline, we found a significant reduction of the E wave peak velocity [79 (64-83) vs. 65 (57-72) cm/s; p = 0.028] and a significant reduction in Vp [84 (73-97) vs. 53 (48-66); p = 0.012]. Moreover, we found a significant reduction in left atrial area [15 (13-18) vs. 12 (10-14) cm2; p = 0.018] and right atrial area [12 (11-15) vs. 11 (9-12) cm2; p = 0.015]. No difference was found in global LV systolic function. The application of PEEP acutely modifies the diastolic flow pattern across the mitral valve, and reduces atrial dimensions.
Cardiopulmonary interactions; Cardiovascular imaging; Non-invasive mechanical ventilation; Positive end-expiratory pressure
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/64920
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