Purpose: Flavonoids have drawn attention because of their antioxidant capacity and anti-carcinogenic effect in various types of cancer. A limited number of studies has investigated their potential effect on the risk of bladder cancer, with inconsistent results. Methods: We analyzed data from an Italian case–control study including 690 incident bladder cancer cases and 665 controls admitted to the same network of hospitals for acute, non-neoplastic, non tobacco-related diseases. Subjects were interviewed using a reproducible and validated food-frequency questionnaire. We applied data on food and beverage composition to estimate the intake of isoflavones, anthocyanidins, flavan-3-ols, flavanones, flavones and flavonols. We estimated odds ratios (ORs) through multiple logistic regression models, including terms for potential confounding factors, including tobacco smoking and total energy intake. Results: We found an inverse association between isoflavones (OR for the highest compared to the lowest quintile of intake = 0.56, 95% CI 0.37–0.84) and flavones (OR = 0.64, 95% CI 0.44–0.95) and bladder cancer. Non-significant inverse association was found for flavan-3-ols (OR = 0.70), flavonols (OR = 0.85) and total flavonoids (OR = 0.76). The results were consistent for non-muscle-invasive and muscle-invasive bladder cancers. Conclusions: Our data indicate an inverse association between isoflavones and flavones with respect to bladder cancer risk.
Flavonoids and bladder cancer risk / M. Rossi, P. Strikoudi, M. Spei, M. Parpinel, D. Serraino, M. Montella, M. Libra, C. La Vecchia, V. Rosato. - In: CANCER CAUSES & CONTROL. - ISSN 0957-5243. - 30:5(2019), pp. 527-535.
|Titolo:||Flavonoids and bladder cancer risk|
ROSATO, VALENTINA (Corresponding)
|Parole Chiave:||Case-control study; Bladder cancer; Flavonoids; Risk factors|
|Settore Scientifico Disciplinare:||Settore MED/01 - Statistica Medica|
|Data di pubblicazione:||2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s10552-019-01158-2|
|Appare nelle tipologie:||01 - Articolo su periodico|
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