High performance gelatin-based biocompatible hybrid hydrogels are developed using functionalized polyethylene glycol as a cross-linker in presence of chitosan or hydroxyethyl cellulose. Tensile test shows robust and tunable mechanical properties and reveals non-linear and J-shaped stress-strain curves similar to those found for native extracellular matrix. Degradation study demonstrates that the mass loss and change in mechanical properties are dependent on hydrogel composition and cross-linking density. Structural features of the hydrogels are confirmed by infrared spectroscopy. A preliminary biological evaluation is carried out using rat myoblasts and human fibroblasts cell lines. The results show that all hydrogels allow cell adhesion and proliferation during four days culture, hence, they might have a great potential for use in the biomedical applications.
Preparation and properties of high performance gelatin-based hydrogels with chitosan or hydroxyethyl cellulose for tissue engineering applications / K. Dey, S. Agnelli, M. Serzanti, P. Ginestra, G. Scarì, P. Dell’Era, L. Sartore. - In: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS. - ISSN 0091-4037. - 68:4(2018), pp. 183-192.
|Titolo:||Preparation and properties of high performance gelatin-based hydrogels with chitosan or hydroxyethyl cellulose for tissue engineering applications|
|Parole Chiave:||Biodegradable; chitosan; gelatin; high performance hybrid hydrogel; J-shaped stress-strain curves; post-curing; tissue engineering|
|Settore Scientifico Disciplinare:||Settore BIO/06 - Anatomia Comparata e Citologia|
|Data di pubblicazione:||2018|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1080/00914037.2018.1429439|
|Appare nelle tipologie:||01 - Articolo su periodico|
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