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Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed LOAD (94,437 individuals). We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (ADAM10, ACE) were identified in a recent genome-wide association (GWAS)-by-familial-proxy of Alzheimer's or dementia. Fine-mapping of the human leukocyte antigen (HLA) region confirms the neurological and immune-mediated disease haplotype HLA-DR15 as a risk factor for LOAD. Pathway analysis implicates immunity, lipid metabolism, tau binding proteins, and amyloid precursor protein (APP) metabolism, showing that genetic variants affecting APP and Aβ processing are associated not only with early-onset autosomal dominant Alzheimer's disease but also with LOAD. Analyses of risk genes and pathways show enrichment for rare variants (P = 1.32 × 10-7), indicating that additional rare variants remain to be identified. We also identify important genetic correlations between LOAD and traits such as family history of dementia and education.
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing / B.W. Kunkle, B. Grenier-Boley, R. Sims, J.C. Bis, V. Damotte, A.C. Naj, A. Boland, M. Vronskaya, S.J. van der Lee, A. Amlie-Wolf, C. Bellenguez, A. Frizatti, V. Chouraki, E.R. Martin, K. Sleegers, N. Badarinarayan, J. Jakobsdottir, K.L. Hamilton-Nelson, S. Moreno-Grau, R. Olaso, R. Raybould, Y. Chen, A.B. Kuzma, M. Hiltunen, T. Morgan, S. Ahmad, B.N. Vardarajan, J. Epelbaum, P. Hoffmann, M. Boada, G.W. Beecham, J. Garnier, D. Harold, A.L. Fitzpatrick, O. Valladares, M. Moutet, A. Gerrish, A.V. Smith, L. Qu, D. Bacq, N. Denning, X. Jian, Y. Zhao, M. Del Zompo, N.C. Fox, S. Choi, I. Mateo, J.T. Hughes, H.H. Adams, J. Malamon, F. Sanchez-Garcia, Y. Patel, J.A. Brody, B.A. Dombroski, M.C.D. Naranjo, M. Daniilidou, G. Eiriksdottir, S. Mukherjee, D. Wallon, J. Uphill, T. Aspelund, L.B. Cantwell, F. Garzia, D. Galimberti, E. Hofer, M. Butkiewicz, B. Fin, E. Scarpini, C. Sarnowski, W.S. Bush, S. Meslage, J. Kornhuber, C.C. White, Y. Song, R.C. Barber, S. Engelborghs, S. Sordon, D. Voijnovic, P.M. Adams, R. Vandenberghe, M. Mayhaus, L.A. Cupples, M.S. Albert, P.P. De Deyn, W. Gu, J.J. Himali, D. Beekly, A. Squassina, A.M. Hartmann, A. Orellana, D. Blacker, E. Rodriguez-Rodriguez, S. Lovestone, M.E. Garcia, R.S. Doody, C. Munoz-Fernadez, R. Sussams, H. Lin, T.J. Fairchild, Y.A. Benito, C. Holmes, H. Karamujić-Čomić, M.P. Frosch, H. Thonberg, W. Maier, G. Roschupkin, B. Ghetti, V. Giedraitis, A. Kawalia, S. Li, R.M. Huebinger, L. Kilander, S. Moebus, I. Hernández, M.I. Kamboh, R. Brundin, J. Turton, Q. Yang, M.J. Katz, L. Concari, J. Lord, A.S. Beiser, C.D. Keene, S. Helisalmi, I. Kloszewska, W.A. Kukull, A.M. Koivisto, A. Lynch, L. Tarraga, E.B. Larson, A. Haapasalo, B. Lawlor, T.H. Mosley, R.B. Lipton, V. Solfrizzi, M. Gill, W.T. Longstreth, T.J. Montine, V. Frisardi, M. Diez-Fairen, F. Rivadeneira, R.C. Petersen, V. Deramecourt, I. Alvarez, F. Salani, A. Ciaramella, E. Boerwinkle, E.M. Reiman, N. Fievet, J.I. Rotter, J.S. Reisch, O. Hanon, C. Cupidi, A.G. Andre Uitterlinden, D.R. Royall, C. Dufouil, R.G. Maletta, I. de Rojas, M. Sano, A. Brice, R. Cecchetti, P.S. George-Hyslop, K. Ritchie, M. Tsolaki, D.W. Tsuang, B. Dubois, D. Craig, C. Wu, H. Soininen, D. Avramidou, R.L. Albin, L. Fratiglioni, A. Germanou, L.G. Apostolova, L. Keller, M. Koutroumani, S.E. Arnold, F. Panza, O. Gkatzima, S. Asthana, D. Hannequin, P. Whitehead, C.S. Atwood, P. Caffarra, H. Hampel, I. Quintela, Á. Carracedo, L. Lannfelt, D.C. Rubinsztein, L.L. Barnes, F. Pasquier, L. Frölich, S. Barral, B. McGuinness, T.G. Beach, J.A. Johnston, J.T. Becker, P. Passmore, E.H. Bigio, J.M. Schott, T.D. Bird, J.D. Warren, B.F. Boeve, M.K. Lupton, J.D. Bowen, P. Proitsi, A. Boxer, J.F. Powell, J.R. Burke, J.S.K. Kauwe, J.M. Burns, M. Mancuso, J.D. Buxbaum, U. Bonuccelli, N.J. Cairns, A. McQuillin, C. Cao, G. Livingston, C.S. Carlson, N.J. Bass, C.M. Carlsson, J. Hardy, R.M. Carney, J. Bras, M.M. Carrasquillo, R. Guerreiro, M. Allen, H.C. Chui, E. Fisher, C. Masullo, E.A. Crocco, C. DeCarli, G. Bisceglio, M. Dick, L. Ma, R. Duara, N.R. Graff-Radford, D.A. Evans, A. Hodges, K.M. Faber, M. Scherer, K.B. Fallon, M. Riemenschneider, D.W. Fardo, R. Heun, M.R. Farlow, H. Kölsch, S. Ferris, M. Leber, T.M. Foroud, I. Heuser, D.R. Galasko, I. Giegling, M. Gearing, M. Hüll, D.H. Geschwind, J.R. Gilbert, J. Morris, R.C. Green, K. Mayo, J.H. Growdon, T. Feulner, R.L. Hamilton, L.E. Harrell, D. Drichel, L.S. Honig, T.D. Cushion, M.J. Huentelman, P. Hollingworth, C.M. Hulette, B.T. Hyman, R. Marshall, G.P. Jarvik, A. Meggy, E. Abner, G.E. Menzies, L. Jin, G. Leonenko, L.M. Real, G.R. Jun, C.T. Baldwin, D. Grozeva, A. Karydas, G. Russo, J.A. Kaye, R. Kim, F. Jessen, N.W. Kowall, B. Vellas, J.H. Kramer, E. Vardy, F.M. LaFerla, K. Jöckel, J.J. Lah, M. Dichgans, J.B. Leverenz, D. Mann, A.I. Levey, S. Pickering-Brown, A.P. Lieberman, N. Klopp, K.L. Lunetta, H. Wichmann, C.G. Lyketsos, K. Morgan, D.C. Marson, K. Brown, F. Martiniuk, C. Medway, D.C. Mash, M.M. Nöthen, E. Masliah, N.M. Hooper, W.C. McCormick, A. Daniele, S.M. McCurry, A. Bayer, A.N. McDavid, J. Gallacher, A.C. McKee, H. van den Bussche, M. Mesulam, C. Brayne, B.L. Miller, S. Riedel-Heller, C.A. Miller, J.W. Miller, A. Al-Chalabi, J.C. Morris, C.E. Shaw, A.J. Myers, J. Wiltfang, S. O'Bryant, J.M. Olichney, V. Alvarez, J.E. Parisi, A.B. Singleton, H.L. Paulson, J. Collinge, W.R. Perry, S. Mead, E. Peskind, D.H. Cribbs, M. Rossor, A. Pierce, N.S. Ryan, W.W. Poon, B. Nacmias, H. Potter, S. Sorbi, J.F. Quinn, E. Sacchinelli, A. Raj, G. Spalletta, M. Raskind, C. Caltagirone, P. Bossù, M.D. Orfei, B. Reisberg, R. Clarke, C. Reitz, A.D. Smith, J.M. Ringman, D. Warden, E.D. Roberson, G. Wilcock, E. Rogaeva, A.C. Bruni, H.J. Rosen, M. Gallo, R.N. Rosenberg, Y. Ben-Shlomo, M.A. Sager, P. Mecocci, A.J. Saykin, P. Pastor, M.L. Cuccaro, J.M. Vance, J.A. Schneider, L.S. Schneider, S. Slifer, W.W. Seeley, A.G. Smith, J.A. Sonnen, S. Spina, R.A. Stern, R.H. Swerdlow, M. Tang, R.E. Tanzi, J.Q. Trojanowski, J.C. Troncoso, V.M. Van Deerlin, L.J. Van Eldik, H.V. Vinters, J.P. Vonsattel, S. Weintraub, K.A. Welsh-Bohmer, K.C. Wilhelmsen, J. Williamson, T.S. Wingo, R.L. Woltjer, C.B. Wright, C. Yu, L. Yu, Y. Saba, A. Pilotto, M.J. Bullido, O. Peters, P.K. Crane, D. Bennett, P. Bosco, E. Coto, V. Boccardi, P.L. De Jager, A. Lleo, N. Warner, O.L. Lopez, M. Ingelsson, P. Deloukas, C. Cruchaga, C. Graff, R. Gwilliam, M. Fornage, A.M. Goate, P. Sanchez-Juan, P.G. Kehoe, N. Amin, N. Ertekin-Taner, C. Berr, S. Debette, S. Love, L.J. Launer, S.G. Younkin, J. Dartigues, C. Corcoran, M.A. Ikram, D.W. Dickson, G. Nicolas, D. Campion, J. Tschanz, H. Schmidt, H. Hakonarson, J. Clarimon, R. Munger, R. Schmidt, L.A. Farrer, C. Van Broeckhoven, M. C O'Donovan, A.L. DeStefano, L. Jones, J.L. Haines, J. Deleuze, M.J. Owen, V. Gudnason, R. Mayeux, V. Escott-Price, B.M. Psaty, A. Ramirez, L. Wang, A. Ruiz, C.M. van Duijn, P.A. Holmans, S. Seshadri, J. Williams, P. Amouyel, G.D. Schellenberg, J. Lambert, M.A. Pericak-Vance. - In: NATURE GENETICS. - ISSN 1061-4036. - 51:3(2019 Mar), pp. 414-430. [10.1038/s41588-019-0358-2]
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Kunkle, Brian W;Grenier-Boley, Benjamin;Sims, Rebecca;Bis, Joshua C;Damotte, Vincent;Naj, Adam C;Boland, Anne;Vronskaya, Maria;van der Lee, Sven J;Amlie-Wolf, Alexandre;Bellenguez, Céline;Frizatti, Aura;Chouraki, Vincent;Martin, Eden R;Sleegers, Kristel;Badarinarayan, Nandini;Jakobsdottir, Johanna;Hamilton-Nelson, Kara L;Moreno-Grau, Sonia;Olaso, Robert;Raybould, Rachel;Chen, Yuning;Kuzma, Amanda B;Hiltunen, Mikko;Morgan, Taniesha;Ahmad, Shahzad;Vardarajan, Badri N;Epelbaum, Jacques;Hoffmann, Per;Boada, Merce;Beecham, Gary W;Garnier, Jean-Guillaume;Harold, Denise;Fitzpatrick, Annette L;Valladares, Otto;Moutet, Marie-Laure;Gerrish, Amy;Smith, Albert V;Qu, Liming;Bacq, Delphine;Denning, Nicola;Jian, Xueqiu;Zhao, Yi;Del Zompo, Maria;Fox, Nick C;Choi, Seung-Hoan;Mateo, Ignacio;Hughes, Joseph T;Adams, Hieab H;Malamon, John;Sanchez-Garcia, Florentino;Patel, Yogen;Brody, Jennifer A;Dombroski, Beth A;Naranjo, Maria Candida Deniz;Daniilidou, Makrina;Eiriksdottir, Gudny;Mukherjee, Shubhabrata;Wallon, David;Uphill, James;Aspelund, Thor;Cantwell, Laura B;Garzia, Fabienne;D. Galimberti;Hofer, Edith;Butkiewicz, Mariusz;Fin, Bertrand;E. Scarpini;Sarnowski, Chloe;Bush, Will S;Meslage, Stéphane;Kornhuber, Johannes;White, Charles C;Song, Yuenjoo;Barber, Robert C;Engelborghs, Sebastiaan;Sordon, Sabrina;Voijnovic, Dina;Adams, Perrie M;Vandenberghe, Rik;Mayhaus, Manuel;Cupples, L Adrienne;Albert, Marilyn S;De Deyn, Peter P;Gu, Wei;Himali, Jayanadra J;Beekly, Duane;Squassina, Alessio;Hartmann, Annette M;Orellana, Adelina;Blacker, Deborah;Rodriguez-Rodriguez, Eloy;Lovestone, Simon;Garcia, Melissa E;Doody, Rachelle S;Munoz-Fernadez, Carmen;Sussams, Rebecca;Lin, Honghuang;Fairchild, Thomas J;Benito, Yolanda A;Holmes, Clive;Karamujić-Čomić, Hata;Frosch, Matthew P;Thonberg, Hakan;Maier, Wolfgang;Roschupkin, Gena;Ghetti, Bernardino;Giedraitis, Vilmantas;Kawalia, Amit;Li, Shuo;Huebinger, Ryan M;Kilander, Lena;Moebus, Susanne;Hernández, Isabel;Kamboh, M Ilyas;Brundin, RoseMarie;Turton, James;Yang, Qiong;Katz, Mindy J;Concari, Letizia;Lord, Jenny;Beiser, Alexa S;Keene, C Dirk;Helisalmi, Seppo;Kloszewska, Iwona;Kukull, Walter A;Koivisto, Anne Maria;Lynch, Aoibhinn;Tarraga, Lluís;Larson, Eric B;Haapasalo, Annakaisa;Lawlor, Brian;Mosley, Thomas H;Lipton, Richard B;Solfrizzi, Vincenzo;Gill, Michael;Longstreth, W T;Montine, Thomas J;Frisardi, Vincenza;Diez-Fairen, Monica;Rivadeneira, Fernando;Petersen, Ronald C;Deramecourt, Vincent;Alvarez, Ignacio;Salani, Francesca;Ciaramella, Antonio;Boerwinkle, Eric;Reiman, Eric M;Fievet, Nathalie;Rotter, Jerome I;Reisch, Joan S;Hanon, Olivier;Cupidi, Chiara;Andre Uitterlinden, A G;Royall, Donald R;Dufouil, Carole;Maletta, Raffaele Giovanni;de Rojas, Itziar;Sano, Mary;Brice, Alexis;Cecchetti, Roberta;George-Hyslop, Peter St;Ritchie, Karen;Tsolaki, Magda;Tsuang, Debby W;Dubois, Bruno;Craig, David;Wu, Chuang-Kuo;Soininen, Hilkka;Avramidou, Despoina;Albin, Roger L;Fratiglioni, Laura;Germanou, Antonia;Apostolova, Liana G;Keller, Lina;Koutroumani, Maria;Arnold, Steven E;Panza, Francesco;Gkatzima, Olymbia;Asthana, Sanjay;Hannequin, Didier;Whitehead, Patrice;Atwood, Craig S;Caffarra, Paolo;Hampel, Harald;Quintela, Inés;Carracedo, Ángel;Lannfelt, Lars;Rubinsztein, David C;Barnes, Lisa L;Pasquier, Florence;Frölich, Lutz;Barral, Sandra;McGuinness, Bernadette;Beach, Thomas G;Johnston, Janet A;Becker, James T;Passmore, Peter;Bigio, Eileen H;Schott, Jonathan M;Bird, Thomas D;Warren, Jason D;Boeve, Bradley F;Lupton, Michelle K;Bowen, James D;Proitsi, Petra;Boxer, Adam;Powell, John F;Burke, James R;Kauwe, John S K;Burns, Jeffrey M;Mancuso, Michelangelo;Buxbaum, Joseph D;Bonuccelli, Ubaldo;Cairns, Nigel J;McQuillin, Andrew;Cao, Chuanhai;Livingston, Gill;Carlson, Chris S;Bass, Nicholas J;Carlsson, Cynthia M;Hardy, John;Carney, Regina M;Bras, Jose;Carrasquillo, Minerva M;Guerreiro, Rita;Allen, Mariet;Chui, Helena C;Fisher, Elizabeth;Masullo, Carlo;Crocco, Elizabeth A;DeCarli, Charles;Bisceglio, Gina;Dick, Malcolm;Ma, Li;Duara, Ranjan;Graff-Radford, Neill R;Evans, Denis A;Hodges, Angela;Faber, Kelley M;Scherer, Martin;Fallon, Kenneth B;Riemenschneider, Matthias;Fardo, David W;Heun, Reinhard;Farlow, Martin R;Kölsch, Heike;Ferris, Steven;Leber, Markus;Foroud, Tatiana M;Heuser, Isabella;Galasko, Douglas R;Giegling, Ina;Gearing, Marla;Hüll, Michael;Geschwind, Daniel H;Gilbert, John R;Morris, John;Green, Robert C;Mayo, Kevin;Growdon, John H;Feulner, Thomas;Hamilton, Ronald L;Harrell, Lindy E;Drichel, Dmitriy;Honig, Lawrence S;Cushion, Thomas D;Huentelman, Matthew J;Hollingworth, Paul;Hulette, Christine M;Hyman, Bradley T;Marshall, Rachel;Jarvik, Gail P;Meggy, Alun;Abner, Erin;Menzies, Georgina E;Jin, Lee-Way;Leonenko, Ganna;Real, Luis M;Jun, Gyungah R;Baldwin, Clinton T;Grozeva, Detelina;Karydas, Anna;Russo, Giancarlo;Kaye, Jeffrey A;Kim, Ronald;Jessen, Frank;Kowall, Neil W;Vellas, Bruno;Kramer, Joel H;Vardy, Emma;LaFerla, Frank M;Jöckel, Karl-Heinz;Lah, James J;Dichgans, Martin;Leverenz, James B;Mann, David;Levey, Allan I;Pickering-Brown, Stuart;Lieberman, Andrew P;Klopp, Norman;Lunetta, Kathryn L;Wichmann, H-Erich;Lyketsos, Constantine G;Morgan, Kevin;Marson, Daniel C;Brown, Kristelle;Martiniuk, Frank;Medway, Christopher;Mash, Deborah C;Nöthen, Markus M;Masliah, Eliezer;Hooper, Nigel M;McCormick, Wayne C;Daniele, Antonio;McCurry, Susan M;Bayer, Anthony;McDavid, Andrew N;Gallacher, John;McKee, Ann C;van den Bussche, Hendrik;Mesulam, Marsel;Brayne, Carol;Miller, Bruce L;Riedel-Heller, Steffi;Miller, Carol A;Miller, Joshua W;Al-Chalabi, Ammar;Morris, John C;Shaw, Christopher E;Myers, Amanda J;Wiltfang, Jens;O'Bryant, Sid;Olichney, John M;Alvarez, Victoria;Parisi, Joseph E;Singleton, Andrew B;Paulson, Henry L;Collinge, John;Perry, William R;Mead, Simon;Peskind, Elaine;Cribbs, David H;Rossor, Martin;Pierce, Aimee;Ryan, Natalie S;Poon, Wayne W;Nacmias, Benedetta;Potter, Huntington;Sorbi, Sandro;Quinn, Joseph F;Sacchinelli, Eleonora;Raj, Ashok;Spalletta, Gianfranco;Raskind, Murray;Caltagirone, Carlo;Bossù, Paola;Orfei, Maria Donata;Reisberg, Barry;Clarke, Robert;Reitz, Christiane;Smith, A David;Ringman, John M;Warden, Donald;Roberson, Erik D;Wilcock, Gordon;Rogaeva, Ekaterina;Bruni, Amalia Cecilia;Rosen, Howard J;Gallo, Maura;Rosenberg, Roger N;Ben-Shlomo, Yoav;Sager, Mark A;Mecocci, Patrizia;Saykin, Andrew J;Pastor, Pau;Cuccaro, Michael L;Vance, Jeffery M;Schneider, Julie A;Schneider, Lori S;Slifer, Susan;Seeley, William W;Smith, Amanda G;Sonnen, Joshua A;Spina, Salvatore;Stern, Robert A;Swerdlow, Russell H;Tang, Mitchell;Tanzi, Rudolph E;Trojanowski, John Q;Troncoso, Juan C;Van Deerlin, Vivianna M;Van Eldik, Linda J;Vinters, Harry V;Vonsattel, Jean Paul;Weintraub, Sandra;Welsh-Bohmer, Kathleen A;Wilhelmsen, Kirk C;Williamson, Jennifer;Wingo, Thomas S;Woltjer, Randall L;Wright, Clinton B;Yu, Chang-En;Yu, Lei;Saba, Yasaman;Pilotto, Alberto;Bullido, Maria J;Peters, Oliver;Crane, Paul K;Bennett, David;Bosco, Paola;Coto, Eliecer;Boccardi, Virginia;De Jager, Phil L;Lleo, Alberto;Warner, Nick;Lopez, Oscar L;Ingelsson, Martin;Deloukas, Panagiotis;Cruchaga, Carlos;Graff, Caroline;Gwilliam, Rhian;Fornage, Myriam;Goate, Alison M;Sanchez-Juan, Pascual;Kehoe, Patrick G;Amin, Najaf;Ertekin-Taner, Nilifur;Berr, Claudine;Debette, Stéphanie;Love, Seth;Launer, Lenore J;Younkin, Steven G;Dartigues, Jean-Francois;Corcoran, Chris;Ikram, M Arfan;Dickson, Dennis W;Nicolas, Gael;Campion, Dominique;Tschanz, JoAnn;Schmidt, Helena;Hakonarson, Hakon;Clarimon, Jordi;Munger, Ron;Schmidt, Reinhold;Farrer, Lindsay A;Van Broeckhoven, Christine;C O'Donovan, Michael;DeStefano, Anita L;Jones, Lesley;Haines, Jonathan L;Deleuze, Jean-Francois;Owen, Michael J;Gudnason, Vilmundur;Mayeux, Richard;Escott-Price, Valentina;Psaty, Bruce M;Ramirez, Alfredo;Wang, Li-San;Ruiz, Agustin;van Duijn, Cornelia M;Holmans, Peter A;Seshadri, Sudha;Williams, Julie;Amouyel, Phillippe;Schellenberg, Gerard D;Lambert, Jean-Charles;Pericak-Vance, Margaret A
2019
Abstract
Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed LOAD (94,437 individuals). We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (ADAM10, ACE) were identified in a recent genome-wide association (GWAS)-by-familial-proxy of Alzheimer's or dementia. Fine-mapping of the human leukocyte antigen (HLA) region confirms the neurological and immune-mediated disease haplotype HLA-DR15 as a risk factor for LOAD. Pathway analysis implicates immunity, lipid metabolism, tau binding proteins, and amyloid precursor protein (APP) metabolism, showing that genetic variants affecting APP and Aβ processing are associated not only with early-onset autosomal dominant Alzheimer's disease but also with LOAD. Analyses of risk genes and pathways show enrichment for rare variants (P = 1.32 × 10-7), indicating that additional rare variants remain to be identified. We also identify important genetic correlations between LOAD and traits such as family history of dementia and education.
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing / B.W. Kunkle, B. Grenier-Boley, R. Sims, J.C. Bis, V. Damotte, A.C. Naj, A. Boland, M. Vronskaya, S.J. van der Lee, A. Amlie-Wolf, C. Bellenguez, A. Frizatti, V. Chouraki, E.R. Martin, K. Sleegers, N. Badarinarayan, J. Jakobsdottir, K.L. Hamilton-Nelson, S. Moreno-Grau, R. Olaso, R. Raybould, Y. Chen, A.B. Kuzma, M. Hiltunen, T. Morgan, S. Ahmad, B.N. Vardarajan, J. Epelbaum, P. Hoffmann, M. Boada, G.W. Beecham, J. Garnier, D. Harold, A.L. Fitzpatrick, O. Valladares, M. Moutet, A. Gerrish, A.V. Smith, L. Qu, D. Bacq, N. Denning, X. Jian, Y. Zhao, M. Del Zompo, N.C. Fox, S. Choi, I. Mateo, J.T. Hughes, H.H. Adams, J. Malamon, F. Sanchez-Garcia, Y. Patel, J.A. Brody, B.A. Dombroski, M.C.D. Naranjo, M. Daniilidou, G. Eiriksdottir, S. Mukherjee, D. Wallon, J. Uphill, T. Aspelund, L.B. Cantwell, F. Garzia, D. Galimberti, E. Hofer, M. Butkiewicz, B. Fin, E. Scarpini, C. Sarnowski, W.S. Bush, S. Meslage, J. Kornhuber, C.C. White, Y. Song, R.C. Barber, S. Engelborghs, S. Sordon, D. Voijnovic, P.M. Adams, R. Vandenberghe, M. Mayhaus, L.A. Cupples, M.S. Albert, P.P. De Deyn, W. Gu, J.J. Himali, D. Beekly, A. Squassina, A.M. Hartmann, A. Orellana, D. Blacker, E. Rodriguez-Rodriguez, S. Lovestone, M.E. Garcia, R.S. Doody, C. Munoz-Fernadez, R. Sussams, H. Lin, T.J. Fairchild, Y.A. Benito, C. Holmes, H. Karamujić-Čomić, M.P. Frosch, H. Thonberg, W. Maier, G. Roschupkin, B. Ghetti, V. Giedraitis, A. Kawalia, S. Li, R.M. Huebinger, L. Kilander, S. Moebus, I. Hernández, M.I. Kamboh, R. Brundin, J. Turton, Q. Yang, M.J. Katz, L. Concari, J. Lord, A.S. Beiser, C.D. Keene, S. Helisalmi, I. Kloszewska, W.A. Kukull, A.M. Koivisto, A. Lynch, L. Tarraga, E.B. Larson, A. Haapasalo, B. Lawlor, T.H. Mosley, R.B. Lipton, V. Solfrizzi, M. Gill, W.T. Longstreth, T.J. Montine, V. Frisardi, M. Diez-Fairen, F. Rivadeneira, R.C. Petersen, V. Deramecourt, I. Alvarez, F. Salani, A. Ciaramella, E. Boerwinkle, E.M. Reiman, N. Fievet, J.I. Rotter, J.S. Reisch, O. Hanon, C. Cupidi, A.G. Andre Uitterlinden, D.R. Royall, C. Dufouil, R.G. Maletta, I. de Rojas, M. Sano, A. Brice, R. Cecchetti, P.S. George-Hyslop, K. Ritchie, M. Tsolaki, D.W. Tsuang, B. Dubois, D. Craig, C. Wu, H. Soininen, D. Avramidou, R.L. Albin, L. Fratiglioni, A. Germanou, L.G. Apostolova, L. Keller, M. Koutroumani, S.E. Arnold, F. Panza, O. Gkatzima, S. Asthana, D. Hannequin, P. Whitehead, C.S. Atwood, P. Caffarra, H. Hampel, I. Quintela, Á. Carracedo, L. Lannfelt, D.C. Rubinsztein, L.L. Barnes, F. Pasquier, L. Frölich, S. Barral, B. McGuinness, T.G. Beach, J.A. Johnston, J.T. Becker, P. Passmore, E.H. Bigio, J.M. Schott, T.D. Bird, J.D. Warren, B.F. Boeve, M.K. Lupton, J.D. Bowen, P. Proitsi, A. Boxer, J.F. Powell, J.R. Burke, J.S.K. Kauwe, J.M. Burns, M. Mancuso, J.D. Buxbaum, U. Bonuccelli, N.J. Cairns, A. McQuillin, C. Cao, G. Livingston, C.S. Carlson, N.J. Bass, C.M. Carlsson, J. Hardy, R.M. Carney, J. Bras, M.M. Carrasquillo, R. Guerreiro, M. Allen, H.C. Chui, E. Fisher, C. Masullo, E.A. Crocco, C. DeCarli, G. Bisceglio, M. Dick, L. Ma, R. Duara, N.R. Graff-Radford, D.A. Evans, A. Hodges, K.M. Faber, M. Scherer, K.B. Fallon, M. Riemenschneider, D.W. Fardo, R. Heun, M.R. Farlow, H. Kölsch, S. Ferris, M. Leber, T.M. Foroud, I. Heuser, D.R. Galasko, I. Giegling, M. Gearing, M. Hüll, D.H. Geschwind, J.R. Gilbert, J. Morris, R.C. Green, K. Mayo, J.H. Growdon, T. Feulner, R.L. Hamilton, L.E. Harrell, D. Drichel, L.S. Honig, T.D. Cushion, M.J. Huentelman, P. Hollingworth, C.M. Hulette, B.T. Hyman, R. Marshall, G.P. Jarvik, A. Meggy, E. Abner, G.E. Menzies, L. Jin, G. Leonenko, L.M. Real, G.R. Jun, C.T. Baldwin, D. Grozeva, A. Karydas, G. Russo, J.A. Kaye, R. Kim, F. Jessen, N.W. Kowall, B. Vellas, J.H. Kramer, E. Vardy, F.M. LaFerla, K. Jöckel, J.J. Lah, M. Dichgans, J.B. Leverenz, D. Mann, A.I. Levey, S. Pickering-Brown, A.P. Lieberman, N. Klopp, K.L. Lunetta, H. Wichmann, C.G. Lyketsos, K. Morgan, D.C. Marson, K. Brown, F. Martiniuk, C. Medway, D.C. Mash, M.M. Nöthen, E. Masliah, N.M. Hooper, W.C. McCormick, A. Daniele, S.M. McCurry, A. Bayer, A.N. McDavid, J. Gallacher, A.C. McKee, H. van den Bussche, M. Mesulam, C. Brayne, B.L. Miller, S. Riedel-Heller, C.A. Miller, J.W. Miller, A. Al-Chalabi, J.C. Morris, C.E. Shaw, A.J. Myers, J. Wiltfang, S. O'Bryant, J.M. Olichney, V. Alvarez, J.E. Parisi, A.B. Singleton, H.L. Paulson, J. Collinge, W.R. Perry, S. Mead, E. Peskind, D.H. Cribbs, M. Rossor, A. Pierce, N.S. Ryan, W.W. Poon, B. Nacmias, H. Potter, S. Sorbi, J.F. Quinn, E. Sacchinelli, A. Raj, G. Spalletta, M. Raskind, C. Caltagirone, P. Bossù, M.D. Orfei, B. Reisberg, R. Clarke, C. Reitz, A.D. Smith, J.M. Ringman, D. Warden, E.D. Roberson, G. Wilcock, E. Rogaeva, A.C. Bruni, H.J. Rosen, M. Gallo, R.N. Rosenberg, Y. Ben-Shlomo, M.A. Sager, P. Mecocci, A.J. Saykin, P. Pastor, M.L. Cuccaro, J.M. Vance, J.A. Schneider, L.S. Schneider, S. Slifer, W.W. Seeley, A.G. Smith, J.A. Sonnen, S. Spina, R.A. Stern, R.H. Swerdlow, M. Tang, R.E. Tanzi, J.Q. Trojanowski, J.C. Troncoso, V.M. Van Deerlin, L.J. Van Eldik, H.V. Vinters, J.P. Vonsattel, S. Weintraub, K.A. Welsh-Bohmer, K.C. Wilhelmsen, J. Williamson, T.S. Wingo, R.L. Woltjer, C.B. Wright, C. Yu, L. Yu, Y. Saba, A. Pilotto, M.J. Bullido, O. Peters, P.K. Crane, D. Bennett, P. Bosco, E. Coto, V. Boccardi, P.L. De Jager, A. Lleo, N. Warner, O.L. Lopez, M. Ingelsson, P. Deloukas, C. Cruchaga, C. Graff, R. Gwilliam, M. Fornage, A.M. Goate, P. Sanchez-Juan, P.G. Kehoe, N. Amin, N. Ertekin-Taner, C. Berr, S. Debette, S. Love, L.J. Launer, S.G. Younkin, J. Dartigues, C. Corcoran, M.A. Ikram, D.W. Dickson, G. Nicolas, D. Campion, J. Tschanz, H. Schmidt, H. Hakonarson, J. Clarimon, R. Munger, R. Schmidt, L.A. Farrer, C. Van Broeckhoven, M. C O'Donovan, A.L. DeStefano, L. Jones, J.L. Haines, J. Deleuze, M.J. Owen, V. Gudnason, R. Mayeux, V. Escott-Price, B.M. Psaty, A. Ramirez, L. Wang, A. Ruiz, C.M. van Duijn, P.A. Holmans, S. Seshadri, J. Williams, P. Amouyel, G.D. Schellenberg, J. Lambert, M.A. Pericak-Vance. - In: NATURE GENETICS. - ISSN 1061-4036. - 51:3(2019 Mar), pp. 414-430. [10.1038/s41588-019-0358-2]
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B.W. Kunkle, B. Grenier-Boley, R. Sims, J.C. Bis, V. Damotte, A.C. Naj, A. Boland, M. Vronskaya, S.J. van der Lee, A. Amlie-Wolf, C. Bellenguez, A. Frizatti, V. Chouraki, E.R. Martin, K. Sleegers, N. Badarinarayan, J. Jakobsdottir, K.L. Hamilton-Nelson, S. Moreno-Grau, R. Olaso, R. Raybould, Y. Chen, A.B. Kuzma, M. Hiltunen, T. Morgan, S. Ahmad, B.N. Vardarajan, J. Epelbaum, P. Hoffmann, M. Boada, G.W. Beecham, J. Garnier, D. Harold, A.L. Fitzpatrick, O. Valladares, M. Moutet, A. Gerrish, A.V. Smith, L. Qu, D. Bacq, N. Denning, X. Jian, Y. Zhao, M. Del Zompo, N.C. Fox, S. Choi, I. Mateo, J.T. Hughes, H.H. Adams, J. Malamon, F. Sanchez-Garcia, Y. Patel, J.A. Brody, B.A. Dombroski, M.C.D. Naranjo, M. Daniilidou, G. Eiriksdottir, S. Mukherjee, D. Wallon, J. Uphill, T. Aspelund, L.B. Cantwell, F. Garzia, D. Galimberti, E. Hofer, M. Butkiewicz, B. Fin, E. Scarpini, C. Sarnowski, W.S. Bush, S. Meslage, J. Kornhuber, C.C. White, Y. Song, R.C. Barber, S. Engelborghs, S. Sordon, D. Voijnovic, P.M. Adams, R. Vandenberghe, M. Mayhaus, L.A. Cupples, M.S. Albert, P.P. De Deyn, W. Gu, J.J. Himali, D. Beekly, A. Squassina, A.M. Hartmann, A. Orellana, D. Blacker, E. Rodriguez-Rodriguez, S. Lovestone, M.E. Garcia, R.S. Doody, C. Munoz-Fernadez, R. Sussams, H. Lin, T.J. Fairchild, Y.A. Benito, C. Holmes, H. Karamujić-Čomić, M.P. Frosch, H. Thonberg, W. Maier, G. Roschupkin, B. Ghetti, V. Giedraitis, A. Kawalia, S. Li, R.M. Huebinger, L. Kilander, S. Moebus, I. Hernández, M.I. Kamboh, R. Brundin, J. Turton, Q. Yang, M.J. Katz, L. Concari, J. Lord, A.S. Beiser, C.D. Keene, S. Helisalmi, I. Kloszewska, W.A. Kukull, A.M. Koivisto, A. Lynch, L. Tarraga, E.B. Larson, A. Haapasalo, B. Lawlor, T.H. Mosley, R.B. Lipton, V. Solfrizzi, M. Gill, W.T. Longstreth, T.J. Montine, V. Frisardi, M. Diez-Fairen, F. Rivadeneira, R.C. Petersen, V. Deramecourt, I. Alvarez, F. Salani, A. Ciaramella, E. Boerwinkle, E.M. Reiman, N. Fievet, J.I. Rotter, J.S. Reisch, O. Hanon, C. Cupidi, A.G. Andre Uitterlinden, D.R. Royall, C. Dufouil, R.G. Maletta, I. de Rojas, M. Sano, A. Brice, R. Cecchetti, P.S. George-Hyslop, K. Ritchie, M. Tsolaki, D.W. Tsuang, B. Dubois, D. Craig, C. Wu, H. Soininen, D. Avramidou, R.L. Albin, L. Fratiglioni, A. Germanou, L.G. Apostolova, L. Keller, M. Koutroumani, S.E. Arnold, F. Panza, O. Gkatzima, S. Asthana, D. Hannequin, P. Whitehead, C.S. Atwood, P. Caffarra, H. Hampel, I. Quintela, Á. Carracedo, L. Lannfelt, D.C. Rubinsztein, L.L. Barnes, F. Pasquier, L. Frölich, S. Barral, B. Mcguinness, T.G. Beach, J.A. Johnston, J.T. Becker, P. Passmore, E.H. Bigio, J.M. Schott, T.D. Bird, J.D. Warren, B.F. Boeve, M.K. Lupton, J.D. Bowen, P. Proitsi, A. Boxer, J.F. Powell, J.R. Burke, J.S.K. Kauwe, J.M. Burns, M. Mancuso, J.D. Buxbaum, U. Bonuccelli, N.J. Cairns, A. Mcquillin, C. Cao, G. Livingston, C.S. Carlson, N.J. Bass, C.M. Carlsson, J. Hardy, R.M. Carney, J. Bras, M.M. Carrasquillo, R. Guerreiro, M. Allen, H.C. Chui, E. Fisher, C. Masullo, E.A. Crocco, C. Decarli, G. Bisceglio, M. Dick, L. Ma, R. Duara, N.R. Graff-Radford, D.A. Evans, A. Hodges, K.M. Faber, M. Scherer, K.B. Fallon, M. Riemenschneider, D.W. Fardo, R. Heun, M.R. Farlow, H. Kölsch, S. Ferris, M. Leber, T.M. Foroud, I. Heuser, D.R. Galasko, I. Giegling, M. Gearing, M. Hüll, D.H. Geschwind, J.R. Gilbert, J. Morris, R.C. Green, K. Mayo, J.H. Growdon, T. Feulner, R.L. Hamilton, L.E. Harrell, D. Drichel, L.S. Honig, T.D. Cushion, M.J. Huentelman, P. Hollingworth, C.M. Hulette, B.T. Hyman, R. Marshall, G.P. Jarvik, A. Meggy, E. Abner, G.E. Menzies, L. Jin, G. Leonenko, L.M. Real, G.R. Jun, C.T. Baldwin, D. Grozeva, A. Karydas, G. Russo, J.A. Kaye, R. Kim, F. Jessen, N.W. Kowall, B. Vellas, J.H. Kramer, E. Vardy, F.M. Laferla, K. Jöckel, J.J. Lah, M. Dichgans, J.B. Leverenz, D. Mann, A.I. Levey, S. Pickering-Brown, A.P. Lieberman, N. Klopp, K.L. Lunetta, H. Wichmann, C.G. Lyketsos, K. Morgan, D.C. Marson, K. Brown, F. Martiniuk, C. Medway, D.C. Mash, M.M. Nöthen, E. Masliah, N.M. Hooper, W.C. Mccormick, A. Daniele, S.M. Mccurry, A. Bayer, A.N. Mcdavid, J. Gallacher, A.C. Mckee, H. van den Bussche, M. Mesulam, C. Brayne, B.L. Miller, S. Riedel-Heller, C.A. Miller, J.W. Miller, A. Al-Chalabi, J.C. Morris, C.E. Shaw, A.J. Myers, J. Wiltfang, S. O'Bryant, J.M. Olichney, V. Alvarez, J.E. Parisi, A.B. Singleton, H.L. Paulson, J. Collinge, W.R. Perry, S. Mead, E. Peskind, D.H. Cribbs, M. Rossor, A. Pierce, N.S. Ryan, W.W. Poon, B. Nacmias, H. Potter, S. Sorbi, J.F. Quinn, E. Sacchinelli, A. Raj, G. Spalletta, M. Raskind, C. Caltagirone, P. Bossù, M.D. Orfei, B. Reisberg, R. Clarke, C. Reitz, A.D. Smith, J.M. Ringman, D. Warden, E.D. Roberson, G. Wilcock, E. Rogaeva, A.C. Bruni, H.J. Rosen, M. Gallo, R.N. Rosenberg, Y. Ben-Shlomo, M.A. Sager, P. Mecocci, A.J. Saykin, P. Pastor, M.L. Cuccaro, J.M. Vance, J.A. Schneider, L.S. Schneider, S. Slifer, W.W. Seeley, A.G. Smith, J.A. Sonnen, S. Spina, R.A. Stern, R.H. Swerdlow, M. Tang, R.E. Tanzi, J.Q. Trojanowski, J.C. Troncoso, V.M. Van Deerlin, L.J. Van Eldik, H.V. Vinters, J.P. Vonsattel, S. Weintraub, K.A. Welsh-Bohmer, K.C. Wilhelmsen, J. Williamson, T.S. Wingo, R.L. Woltjer, C.B. Wright, C. Yu, L. Yu, Y. Saba, A. Pilotto, M.J. Bullido, O. Peters, P.K. Crane, D. Bennett, P. Bosco, E. Coto, V. Boccardi, P.L. De Jager, A. Lleo, N. Warner, O.L. Lopez, M. Ingelsson, P. Deloukas, C. Cruchaga, C. Graff, R. Gwilliam, M. Fornage, A.M. Goate, P. Sanchez-Juan, P.G. Kehoe, N. Amin, N. Ertekin-Taner, C. Berr, S. Debette, S. Love, L.J. Launer, S.G. Younkin, J. Dartigues, C. Corcoran, M.A. Ikram, D.W. Dickson, G. Nicolas, D. Campion, J. Tschanz, H. Schmidt, H. Hakonarson, J. Clarimon, R. Munger, R. Schmidt, L.A. Farrer, C. Van Broeckhoven, M. C O'Donovan, A.L. Destefano, L. Jones, J.L. Haines, J. Deleuze, M.J. Owen, V. Gudnason, R. Mayeux, V. Escott-Price, B.M. Psaty, A. Ramirez, L. Wang, A. Ruiz, C.M. van Duijn, P.A. Holmans, S. Seshadri, J. Williams, P. Amouyel, G.D. Schellenberg, J. Lambert, M.A. Pericak-Vance
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simulazione ASN
Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande.