Here we describe a case of an HIV-infected young woman with extensive drug-resistant virus, who was successfully switched from a raltegravir-based regimen to a dolutegravir-based intensified antiretroviral regimen a few days before scheduled caesarean section because of the still detectable viral load. The trough concentrations of all antiretroviral drugs before and after delivery are also described. Our case underlines both the difficult management of young women, HIV-infected at young age with very limited treatment options and the great variability in the pregnancy-related physiological changes affecting the pharmacokinetics of antiretrovirals.
Pregnancy-related changes of antiretroviral pharmacokinetics: an argument for therapeutic drug monitoring / F.R. Simonetti, D. Cattaneo, N. Zanchetta, V. Giacomet, V. Micheli, N. Ciminera, C. Gervasoni. - In: ANTIVIRAL THERAPY. - ISSN 2040-2058. - 22:4(2017), pp. 361-363.
Titolo: | Pregnancy-related changes of antiretroviral pharmacokinetics: an argument for therapeutic drug monitoring |
Autori: | |
Parole Chiave: | Adult; Anti-HIV Agents; Biological Availability; Cesarean Section; Drug Administration Schedule; Drug Resistance, Viral; Female; HIV Infections; HIV-1; Heterocyclic Compounds, 3-Ring; Humans; Mutation; Pregnancy; Raltegravir Potassium; Viral Load; Drug Monitoring; Drug Substitution |
Settore Scientifico Disciplinare: | Settore MED/38 - Pediatria Generale e Specialistica |
Data di pubblicazione: | 2017 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.3851/IMP3122 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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