Recent results show that in mainland Italian children with Autism spectrum disorder (ASD), HLA-G coding alleles distribution is skewed and an association between HLA-G*01:05N and ASD is present. Herein, in an independent cohort of Sardinian ASD (sASD) children and their relatives, we verify whether HLA-G allele association with ASD could be confirmed in this genetically peculiar insular population. One hundred children with a diagnosis of ASD, born in Sardinia and of Sardinian descent, 91 of their mothers, and 40 of their healthy siblings were enrolled. DNA sequencing analysis of HLA-G exon 2, 3 and 4 was used to obtain HLA-G allelic frequencies. Alleles distribution was compared with that of continental ASD children and with a control group of Caucasoid couples of multiparous women and their partners from Brazil and Denmark. Skewing of HLA-G allele distribution was replicated in sASD children; in particular, the HLA-G*01:03 allele, associated with reduced fetal tolerogenicity and development of myeloid leukemia, was more common in both ASD groups compared to controls (p c = 1 × 10 −3 ; OR:3.5, 95%CI: 1.8–6.8). However, given the lack of data on HLA-G*01:03 allelic distribution among Sardinian healthy subjects, we cannot exclude a population effect. These data confirm an association of HLA-G locus with ASD development, particularly with those alleles linked to a lower expression of tolerogenic HLA-G protein, thus warranting further studies on HLA-G polymorphism distribution in different ASD populations.
HLA-G allelic distribution in Sardinian children with Autism spectrum disorders: A replication study / F.R. Guerini, E. Bolognesi, S. Sotgiu, A. Carta, C. Clerici, M. Chiappedi, A. Ghezzo, M. Zanette, M.M. Mensi, M.P. Canevini, M. Zanzottera, C. Agliardi, A.S. Costa, U. Balottin, M. Clerici. - In: BRAIN BEHAVIOR AND IMMUNITY. - ISSN 0889-1591. - 79(2019 Jul), pp. 314-318.
|Titolo:||HLA-G allelic distribution in Sardinian children with Autism spectrum disorders: A replication study|
GUERINI, FRANCA ROSA (Primo) (Corresponding)
CLERICI, MARIO SALVATORE (Ultimo)
|Parole Chiave:||Autistic spectrum disorder; Genetic polymorphism; HLA-G; Immune system; In utero immunology; KIR; NK cells; Immunology; Endocrine and Autonomic Systems; Behavioral Neuroscience|
|Settore Scientifico Disciplinare:||Settore MED/39 - Neuropsichiatria Infantile|
Settore MED/04 - Patologia Generale
|Data di pubblicazione:||lug-2019|
|Data ahead of print / Data di stampa:||11-feb-2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.bbi.2019.02.003|
|Appare nelle tipologie:||01 - Articolo su periodico|