Objective: To evaluate the effect of fetal sex on singleton pregnancy growth charts customized for parental characteristics, race, and parity Methods: In a multicentric cross-sectional study, 8070 ultrasonographic examinations from low-risk singleton pregnancies between 16 and 40 weeks of gestation were considered. The fetal measurements obtained were biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC), and femur length (FL). Quantile regression was used to examine the impact of fetal sex across the biometric percentiles of the fetal measurements considered together with parents’ height, weight, parity, and race. Results: Fetal gender resulted to be a significant covariate for BDP, HC, and AC with higher values for male fetuses (p ≤ 0.0009). Minimal differences were found among sexes for FL. Parity, maternal race, paternal height and maternal height, and weight resulted significantly related to the fetal biometric parameters considered independently from fetal gender. Conclusion: In this study, we constructed customized biometric growth charts for fetal sex, parental, and obstetrical characteristics using quantile regression. The use of gender-specific charts offers the advantage to define individualized normal ranges of fetal biometric parameters at each specific centile. This approach may improve the antenatal identification of abnormal fetal growth.

The effect of fetal sex on customized fetal growth charts / G. Rizzo, F. Prefumo, E. Ferrazzi, C. Zanardini, D. Di Martino, S. Boito, E. Aiello, T. Ghi, G. Altobelli, L.M.A. Arduini, G. Canzone, A. Capece, E. Carboni, L. Cariello, E. Cariati, I. Cetin, N. Chianchiano, G. Clerici, V. D’Addario, D. Di Martino, E. Cosmi, R. Giacchello, A. Giancotti, M. Giorgina, A. Maiandi, L. Mandia, G. Maruotti, A. Mazzocco, L. Nicoletti, E. Periti, N. Persico, A. Rossi, T. Stampalija, A. Tenore, T. Todros, S. Visentin, C. Verrotti, E. Viora, P. Volpe. - In: THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE. - ISSN 1476-7058. - 29:23(2016), pp. 3768-3775. [10.3109/14767058.2016.1149565]

The effect of fetal sex on customized fetal growth charts

E. Ferrazzi;D. Di Martino;T. Ghi;I. Cetin;D. Di Martino;L. Mandia;L. Nicoletti;N. Persico;T. Stampalija;
2016

Abstract

Objective: To evaluate the effect of fetal sex on singleton pregnancy growth charts customized for parental characteristics, race, and parity Methods: In a multicentric cross-sectional study, 8070 ultrasonographic examinations from low-risk singleton pregnancies between 16 and 40 weeks of gestation were considered. The fetal measurements obtained were biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC), and femur length (FL). Quantile regression was used to examine the impact of fetal sex across the biometric percentiles of the fetal measurements considered together with parents’ height, weight, parity, and race. Results: Fetal gender resulted to be a significant covariate for BDP, HC, and AC with higher values for male fetuses (p ≤ 0.0009). Minimal differences were found among sexes for FL. Parity, maternal race, paternal height and maternal height, and weight resulted significantly related to the fetal biometric parameters considered independently from fetal gender. Conclusion: In this study, we constructed customized biometric growth charts for fetal sex, parental, and obstetrical characteristics using quantile regression. The use of gender-specific charts offers the advantage to define individualized normal ranges of fetal biometric parameters at each specific centile. This approach may improve the antenatal identification of abnormal fetal growth.
Customized growth chart; fetal biometry; gender difference; quantile regression; Biometry; Cross-Sectional Studies; Female; Fetal Development; Gestational Age; Humans; Italy; Male; Pregnancy; Reference Values; Regression Analysis; Ultrasonography, Prenatal; Growth Charts; Sex Factors; Pediatrics, Perinatology and Child Health; Obstetrics and Gynecology
Settore MED/40 - Ginecologia e Ostetricia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/623826
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