Background The aim of the present systematic review was to evaluate the hypothesis of an association between periodontitis and the development of cancer. Methods Two reviewers independently screened electronic and manual sources for pertinent articles. Primary outcome measures were the occurrence of neoplasm diagnosis in exposed and non-exposed groups, reported to evaluate association between cancer and periodontitis. Results Of the 490 initially retrieved papers 10 were included in the qualitative synthesis and eight in the quantitative synthesis; the eight papers covered six studies. Considering hazard ratios, a statistically significant association was found for all cancers studied (1.14; CI 95%: 1.04, 1.24), digestive tract cancer (1.34; CI 95%: 1.05, 1.72), pancreatic cancer (1.74; CI 95%: 1.21, 2.52), prostate cancer (1.25; CI 95%: 1.04, 1.51), breast cancer (1.11; CI 95%: 1.00, 1.23), corpus uteri cancer (2.20; CI 95%: 1.16, 4.18), lung cancer (1.24; CI 95%: 1.06, 1.45), hematological cancer (1.30; CI 95%: 1.11, 1.53), esophagus / oropharyngeal cancer pooled together (2.25; CI 95%: 1.30, 3.90) and Non-Hodgkin lymphoma (1.30; CI 95%: 1.11, 1.52). Conclusions Despite the sparse scientific evidence and considering the low statistical power of the results, this systematic review revealed a substantial lack of studies with standardized and comparable methods to speculate about the association between periodontitis and cancer; more studies are need in order to explore further the scientific evidence of such correlation.
Is periodontitis a risk indicator for cancer? A meta-analysis / S. Corbella, P. Veronesi, V. Galimberti, R. Weinstein, M.D. Fabbro, L. Francetti. - In: PLOS ONE. - ISSN 1932-6203. - 13:4(2018), pp. e0195683.1-e0195683.15.
|Titolo:||Is periodontitis a risk indicator for cancer? A meta-analysis|
CORBELLA, STEFANO (Corresponding)
|Parole Chiave:||Humans; Neoplasms; Periodontitis; Prognosis; Risk Factors; Biochemistry, Genetics and Molecular Biology (all); Agricultural and Biological Sciences (all)|
|Settore Scientifico Disciplinare:||Settore MED/28 - Malattie Odontostomatologiche|
Settore MED/50 - Scienze Tecniche Mediche Applicate
Settore MED/18 - Chirurgia Generale
|Data di pubblicazione:||2018|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1371/journal.pone.0195683|
|Appare nelle tipologie:||01 - Articolo su periodico|
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