The aim of this study was to investigate the relation between bladder cancer risk and the use of selected drugs for cardiovascular disease (CVD) prevention, such as aspirin, statins, and calcium channel blockers (CCBs). We analyzed data from a multicentric case-control study carried out in Italy between 2003 and 2014, including 690 bladder cancer cases and 665 hospital controls. Odds ratios (ORs) of bladder cancer and corresponding 95% confidence intervals (CIs) were estimated using unconditional multiple logistic regression models. The ORs for bladder cancer were 1.21 (95% CI: 0.87-1.68) for regular use of aspirin, 0.72 (95% CI: 0.54-0.97) for use of any CCBs, and 1.32 (95% CI: 0.87-1.99) for use of any statins. A slight inverse association was found with duration of use of CCBs, whereas no consistent association was found with duration of use, age at first use, and frequency for aspirin and statin use, or with indication of use for aspirin (as an analgesic or, for CVD prevention). No significant association was found for various combinations of drugs or for all drugs combined (OR=1.23, 95% CI: 0.31-4.85). Our data indicate the lack of a relevant association between the use of selected drugs for CVD prevention and bladder cancer risk, although suggest a potential favorable role for CCBs.

Bladder cancer risk in users of selected drugs for cardiovascular disease prevention / V. Guercio, F. Turati, C. Bosetti, J. Polesel, D. Serraino, M. Montella, M. Libra, A. Galfano, C. La Vecchia, A. Tavani. - In: EUROPEAN JOURNAL OF CANCER PREVENTION. - ISSN 0959-8278. - 28:2(2017 Dec 28), pp. 76-80. [Epub ahead of print]

Bladder cancer risk in users of selected drugs for cardiovascular disease prevention

V. Guercio
Primo
;
F. Turati
Secondo
;
C. La Vecchia
Penultimo
;
2017-12-28

Abstract

The aim of this study was to investigate the relation between bladder cancer risk and the use of selected drugs for cardiovascular disease (CVD) prevention, such as aspirin, statins, and calcium channel blockers (CCBs). We analyzed data from a multicentric case-control study carried out in Italy between 2003 and 2014, including 690 bladder cancer cases and 665 hospital controls. Odds ratios (ORs) of bladder cancer and corresponding 95% confidence intervals (CIs) were estimated using unconditional multiple logistic regression models. The ORs for bladder cancer were 1.21 (95% CI: 0.87-1.68) for regular use of aspirin, 0.72 (95% CI: 0.54-0.97) for use of any CCBs, and 1.32 (95% CI: 0.87-1.99) for use of any statins. A slight inverse association was found with duration of use of CCBs, whereas no consistent association was found with duration of use, age at first use, and frequency for aspirin and statin use, or with indication of use for aspirin (as an analgesic or, for CVD prevention). No significant association was found for various combinations of drugs or for all drugs combined (OR=1.23, 95% CI: 0.31-4.85). Our data indicate the lack of a relevant association between the use of selected drugs for CVD prevention and bladder cancer risk, although suggest a potential favorable role for CCBs.
aspirin; calcium channel blockers; case-control study; bladder cancer; risk factor; statins
Settore MED/01 - Statistica Medica
mar-2019
Article (author)
File in questo prodotto:
File Dimensione Formato  
bladder cancer-GUERCIO 17-16623.pdf

accesso aperto

Tipologia: Pre-print (manoscritto inviato all'editore)
Dimensione 752.17 kB
Formato Adobe PDF
752.17 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/617314
Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 5
social impact