Objective: To investigate the relationship between oxytocin, menopause and obesity. Methods: A cross-sectional analysis on 56 obese (OB; 28 premenopausal) and 53 normal-weight women (NW; 27 premenopausal) was performed by measurement of oxytocin, leptin, adiponectin, gonadotropins, sex steroids, glucose, and lipid homeostasis as well as DXA assessment of fat mass (%FM) and fat-free mass (FFM). Results: Women from NW and OB groups were comparable for age but differed in anthropometric measures. In our cohorts, menopause was not associated with changes in gluco-lipid homeostasis and %FM, while FFM was lower in postmenopausal women from both study groups (p < 0.05). In each group, leptin was unaltered, and adiponectin only marginally changed across menopause, while oxytocin levels were lower in post-than in premenopausal women (NW: P < 0.05; OB: P < 0.005), and lower in OB than NW women, either when assessed as whole groups or if stratified by menopause (p < 0.001). In correlation analysis, inverse associations related oxytocin to menopause, obesity, and adiposity-related measures. BMI (p < 0.0001) and menopause independently predicted oxytocin levels (p < 0.001), but their interaction was null (p = 0.5). Conclusions: Obesity and menopause are independent negative predictors of plasma oxytocin. Longitudinal studies should clarify the role of oxytocin on weight modifications experienced around and after menopause.
Plasma Oxytocin Concentration in Pre- and Postmenopausal Women: Its Relationship with Obesity, Body Composition and Metabolic Variables / S. Maestrini, C. Mele, S. Mai, R. Vietti, A. Di Blasio, L. Castello, D. Surico, G. Aimaretti, M. Scacchi, P. Marzullo. - In: OBESITY FACTS. - ISSN 1662-4025. - 11:5(2018 Nov 01), pp. 429-439.
|Titolo:||Plasma Oxytocin Concentration in Pre- and Postmenopausal Women: Its Relationship with Obesity, Body Composition and Metabolic Variables|
SCACCHI, MASSIMO (Penultimo)
|Parole Chiave:||body composition; menopause; obesity; oxytocin; health (social science); physiology (medical)|
|Settore Scientifico Disciplinare:||Settore MED/13 - Endocrinologia|
|Data di pubblicazione:||1-nov-2018|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1159/000492001|
|Appare nelle tipologie:||01 - Articolo su periodico|