Objectives: To evaluate the effects of repeated cerebrospinal fluid (CSF) tap procedures in idiopathic normal pressure hydrocephalus (iNPH) patients ineligible for surgical treatment. Design: Prospective, monocentric, pilot study. Setting: University hospital. Participants: Thirty-nine patients aged 75 years and older, ineligible for shunting surgical intervention. Intervention: Repeated CSF taps. Measurements: All patients underwent a comprehensive geriatric assessment before and after each CSF tap. Adverse events were recorded. Results: No major side effect was reported. Eleven patients showed no response to the first CSF tap test and were excluded. In the remaining 28 patients, all physical and cognitive functions improved after the drainage procedures, except for continence (which seemed poorly influenced). According to clinical judgment, the mean time frame of benefit between CSF taps was 7 months. Patients withdrawing from the protocol during the clinical follow-up showed a worsening of functional and cognitive performances after the interruption. Conclusions/Implications: Periodic CSF therapeutic taps are safe, allow a better control of iNPH symptoms, and prevent functional decline in geriatric patients.

Repeated Cerebrospinal Fluid Removal Procedure in Older Patients With Idiopathic Normal Pressure Hydrocephalus Ineligible for Surgical Treatment / P. Dionigi Rossi, S. Damanti, C. Nani, M. Pluderi, G.A. Bertani, D. Mari, M. Cesari, D. Consonni, D. Spagnoli. - In: JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. - ISSN 1538-9375. - (2019). [Epub ahead of print] [10.1016/j.jamda.2018.11.014]

Repeated Cerebrospinal Fluid Removal Procedure in Older Patients With Idiopathic Normal Pressure Hydrocephalus Ineligible for Surgical Treatment

S. Damanti
Secondo
;
C. Nani;M. Pluderi;G.A. Bertani;D. Mari;M. Cesari;
2019

Abstract

Objectives: To evaluate the effects of repeated cerebrospinal fluid (CSF) tap procedures in idiopathic normal pressure hydrocephalus (iNPH) patients ineligible for surgical treatment. Design: Prospective, monocentric, pilot study. Setting: University hospital. Participants: Thirty-nine patients aged 75 years and older, ineligible for shunting surgical intervention. Intervention: Repeated CSF taps. Measurements: All patients underwent a comprehensive geriatric assessment before and after each CSF tap. Adverse events were recorded. Results: No major side effect was reported. Eleven patients showed no response to the first CSF tap test and were excluded. In the remaining 28 patients, all physical and cognitive functions improved after the drainage procedures, except for continence (which seemed poorly influenced). According to clinical judgment, the mean time frame of benefit between CSF taps was 7 months. Patients withdrawing from the protocol during the clinical follow-up showed a worsening of functional and cognitive performances after the interruption. Conclusions/Implications: Periodic CSF therapeutic taps are safe, allow a better control of iNPH symptoms, and prevent functional decline in geriatric patients.
Idiopathic normal pressure hydrocephalus; elderly; lumbar puncture
Settore MED/09 - Medicina Interna
Article (author)
File in questo prodotto:
File Dimensione Formato  
Repeated cerebrospinal fluid removal procedeure in older patients with idopathic normal pressure hyrdocephalus ineligible for surgical treatment.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 566.09 kB
Formato Adobe PDF
566.09 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/613733
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 7
social impact