An efficient selective synthesis of methyl dithienyl-glycolates has been developed. The interest of this two steps protocol resides in the possibility of synthesized either methyl 2,2-dithienyl glycolate – the target intermediate for the preparation of anticholinergic agents – or its regio-isomer methyl 2,3-dithienyl glycolate – the most critical precursor of anticholinergic drug impurity.

Selective synthesis of methyl dithienyl-glycolates / F. Foschi, E. Bonandi, A. Mereu, B. Pacchetti, D. Gozzini, D. Passarella. - In: ARKIVOC. - ISSN 1551-7012. - 2018:7(2018 Dec), pp. 423-430. [10.24820/ark.5550190.p010.717]

Selective synthesis of methyl dithienyl-glycolates

F. Foschi;E. Bonandi;D. Gozzini;D. Passarella
2018-12

Abstract

An efficient selective synthesis of methyl dithienyl-glycolates has been developed. The interest of this two steps protocol resides in the possibility of synthesized either methyl 2,2-dithienyl glycolate – the target intermediate for the preparation of anticholinergic agents – or its regio-isomer methyl 2,3-dithienyl glycolate – the most critical precursor of anticholinergic drug impurity.
Bromothiophene lithiation; dithienyl glycolate; muscarinic antagonist; COPD
Settore CHIM/06 - Chimica Organica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/608435
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