An efficient selective synthesis of methyl dithienyl-glycolates has been developed. The interest of this two steps protocol resides in the possibility of synthesized either methyl 2,2-dithienyl glycolate – the target intermediate for the preparation of anticholinergic agents – or its regio-isomer methyl 2,3-dithienyl glycolate – the most critical precursor of anticholinergic drug impurity.
Selective synthesis of methyl dithienyl-glycolates / F. Foschi, E. Bonandi, A. Mereu, B. Pacchetti, D. Gozzini, D. Passarella. - In: ARKIVOC. - ISSN 1551-7012. - 2018:7(2018 Dec), pp. 423-430. [10.24820/ark.5550190.p010.717]
Selective synthesis of methyl dithienyl-glycolates
F. Foschi;E. Bonandi;D. Gozzini;D. Passarella
2018-12
Abstract
An efficient selective synthesis of methyl dithienyl-glycolates has been developed. The interest of this two steps protocol resides in the possibility of synthesized either methyl 2,2-dithienyl glycolate – the target intermediate for the preparation of anticholinergic agents – or its regio-isomer methyl 2,3-dithienyl glycolate – the most critical precursor of anticholinergic drug impurity.
| File | Dimensione | Formato | |
|---|---|---|---|
|
18-10717IP.pdf
accesso aperto
Tipologia:
Publisher's version/PDF
Dimensione
535.07 kB
Formato
Adobe PDF
|
535.07 kB | Adobe PDF | Visualizza/Apri |
|
18-10717IP.pdf
accesso aperto
Tipologia:
Publisher's version/PDF
Dimensione
516.91 kB
Formato
Adobe PDF
|
516.91 kB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
