An efficient selective synthesis of methyl dithienyl-glycolates has been developed. The interest of this two steps protocol resides in the possibility of synthesized either methyl 2,2-dithienyl glycolate – the target intermediate for the preparation of anticholinergic agents – or its regio-isomer methyl 2,3-dithienyl glycolate – the most critical precursor of anticholinergic drug impurity.
Selective synthesis of methyl dithienyl-glycolates / F. Foschi, E. Bonandi, A. Mereu, B. Pacchetti, D. Gozzini, D. Passarella. - In: ARKIVOC. - ISSN 1551-7012. - 2018:7(2018 Dec), pp. 423-430.
Titolo: | Selective synthesis of methyl dithienyl-glycolates |
Autori: | PASSARELLA, DANIELE (Corresponding) |
Parole Chiave: | Bromothiophene lithiation; dithienyl glycolate; muscarinic antagonist; COPD |
Settore Scientifico Disciplinare: | Settore CHIM/06 - Chimica Organica |
Data di pubblicazione: | dic-2018 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.24820/ark.5550190.p010.717 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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