The link between chromosome structure and function is a challenging open question because chromosomes in vivo are highly dynamic and arduous to manipulate. Here, we examine several promising approaches to tackle this question specifically in bacteria, by integrating knowledge from different sources. Toward this end, we first provide a brief overview of experimental tools that have provided insights into the description of the bacterial chromosome, including genetic, biochemical and fluorescence microscopy techniques. We then explore the possibility of using comparative genomics to isolate functionally important features of chromosome organization, exploiting the fact that features shared between phylogenetically distant bacterial species reflect functional significance. Finally, we discuss possible future perspectives from the field of experimental evolution. Specifically, we propose novel experiments in which bacteria could be screened and selected on the basis of the structural properties of their chromosomes.
From structure to function of bacterial chromosomes : evolutionary perspectives and ideas for new experiments / M. Cosentino Lagomarsino, O. Espéli, I. Junier. - In: FEBS LETTERS. - ISSN 0014-5793. - 589:20(2015), pp. 2996-3004.
|Titolo:||From structure to function of bacterial chromosomes : evolutionary perspectives and ideas for new experiments|
COSENTINO LAGOMARSINO, MARCO (Corresponding)
|Parole Chiave:||Bacteria, genetics; Chromosome Segregation; Chromosomes, Bacterial, physiology, ultrastructure; DNA Replication; DNA, Bacterial, genetics; Evolution, Molecular; Gene Expression Regulation, Bacterial; Genetic Loci; Genome, Bacterial; Bacterial chromosomes; Chromosome organization; Comparative genomics; Genome organization; Selection devices; Structure-function relationship|
|Settore Scientifico Disciplinare:||Settore FIS/02 - Fisica Teorica, Modelli e Metodi Matematici|
Settore BIO/11 - Biologia Molecolare
Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Settore FIS/03 - Fisica della Materia
|Data di pubblicazione:||2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.febslet.2015.07.002|
|Appare nelle tipologie:||01 - Articolo su periodico|