Staged leg lengthening allows achondroplastic dwarf to reach nearly normal height, but it takes long periods of external fixation and it can be burdened by delayed unions.Between 2009 and 2013 eight achondroplastic dwarfs showed delayed unions in the callus formation during femoral lengthening stages in our institute.We performed in-situ injection of bone marrow- derived stem cell concentrates: Patients underwent monthly clinical and radiographic assessment for determination of the healing rate. All eight patients showed an improvement in the regenerate bone, with an average healing index of 23.1 days/cm (range: 18.7-23.8 days(cm). The complete recovery of the delayed consolidation took on an average of 5.2 months (range: 2-10 months). The use of cellular therapy in these patients could represent an innovative application.

Mesenchymal stem cells as adjuvant therapy for limb lengthening in achondroplasia / A. Memeo, F. Verdoni, C. Ingraffia, L. Rossi, L. Pedretti, R. D'Amato, L. Peretto, G.V. Mineo. - In: JOURNAL OF PEDIATRIC ORTHOPAEDICS B. - ISSN 1060-152X. - (2018 Nov 15). [Epub ahead of print] [10.1097/BPB.0000000000000571]

Mesenchymal stem cells as adjuvant therapy for limb lengthening in achondroplasia

L. Pedretti
Writing – Original Draft Preparation
;
R.D. D'Amato;G.V. Mineo
Supervision
2018-11-15

Abstract

Staged leg lengthening allows achondroplastic dwarf to reach nearly normal height, but it takes long periods of external fixation and it can be burdened by delayed unions.Between 2009 and 2013 eight achondroplastic dwarfs showed delayed unions in the callus formation during femoral lengthening stages in our institute.We performed in-situ injection of bone marrow- derived stem cell concentrates: Patients underwent monthly clinical and radiographic assessment for determination of the healing rate. All eight patients showed an improvement in the regenerate bone, with an average healing index of 23.1 days/cm (range: 18.7-23.8 days(cm). The complete recovery of the delayed consolidation took on an average of 5.2 months (range: 2-10 months). The use of cellular therapy in these patients could represent an innovative application.
Achondroplasia; bone marrow aspirate concentrate; delayed union; external fixation; limb lengthening; mesenchymal stem cells
Settore MED/33 - Malattie Apparato Locomotore
15-nov-2018
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/602204
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